ML-7 HYDROCHLORIDE
- CAS No.
- 110448-33-4
- Chemical Name:
- ML-7 HYDROCHLORIDE
- Synonyms
- ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
- CBNumber:
- CB9183931
- Molecular Formula:
- C15H18ClIN2O2S
- Molecular Weight:
- 452.74
- MDL Number:
- MFCD00065524
- MOL File:
- 110448-33-4.mol
- MSDS File:
- SDS
ML-7 HYDROCHLORIDE price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I2764 | ML-7 powder | 110448-33-4 | 5mg | $163 | 2024-03-01 | Buy |
Sigma-Aldrich | 475880 | ML-7, Hydrochloride | 110448-33-4 | 1mg | $187 | 2024-03-01 | Buy |
Cayman Chemical | 11801 | ML-7 (hydrochloride) ≥95% | 110448-33-4 | 5mg | $61 | 2024-03-01 | Buy |
Cayman Chemical | 11801 | ML-7 (hydrochloride) ≥95% | 110448-33-4 | 1mg | $31 | 2023-06-20 | Buy |
Cayman Chemical | 11801 | ML-7 (hydrochloride) ≥95% | 110448-33-4 | 10mg | $96 | 2024-03-01 | Buy |
ML-7 HYDROCHLORIDE Chemical Properties,Uses,Production
Description
ML-
Chemical Properties
Off-White to Yellow Fine Crystalline Solid
Uses
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
Uses
A potent and selective inhibitor of myosin light chain kinase.
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
in vitro
rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
in vivo
administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
storage
room temperature (desiccate)
References
[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
ML-7 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from ML-7 HYDROCHLORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-09-08 | ML-7 HYDROCHLORIDE
110448-33-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2019-12-24 | ML-7 HYDROCHLORIDE
110448-33-4
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
- ML-7 HYDROCHLORIDE
110448-33-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- ML-7 HYDROCHLORIDE
110448-33-4
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co