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Nortadalafil

Nortadalafil structure

CAS No.: 171596-36-4

Chemical Name:: Nortadalafil

Synonyms: Nortadalafil;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;Demethyltadalafil impurity;Tadalafil IMpurity:IMpurity C;Tadanafil N-desmethyl impurity;Nortadalafil/Demethyl Tadalafil

CBNumber:: CB92549609

Molecular Formula:: C21H17N3O4

Molecular Weight:: 375.38

MDL Number:: MFCD19443817

MOL File:: 171596-36-4.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:12

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Nortadalafil Properties

Melting point	285-290℃ (methanol )
Boiling point	718.6±60.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	13.53±0.40(Predicted)
color	White to Pale Yellow
FDA UNII	5W59DMB3LD

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H302+H312-H314-H317-H410
Precautionary statements	P501-P273-P272-P260-P270-P264-P280-P391-P362+P364-P303+P361+P353-P333+P313-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405

Nortadalafil price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D293800	N-DesmethylTadalafil	171596-36-4	5mg	$185	2021-12-16	Buy
ApexBio Technology	A3665	Nortadalafil	171596-36-4	5mg	$213	2021-12-16	Buy
Biosynth Carbosynth	FD21326	N-Desmethyl tadalafil	171596-36-4	5mg	$285	2021-12-16	Buy
American Custom Chemicals Corporation	API0010360	NORTADALAFIL 95.00%	171596-36-4	5MG	$322.3	2021-12-16	Buy
ApexBio Technology	A3665	Nortadalafil	171596-36-4	10mg	$331	2021-12-16	Buy

Product number	Packaging	Price	Buy
D293800	5mg	$185	Buy
A3665	5mg	$213	Buy
FD21326	5mg	$285	Buy
API0010360	5MG	$322.3	Buy
A3665	10mg	$331	Buy

Nortadalafil Chemical Properties,Uses,Production

Uses

A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.

Biological Activity

the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.

in vitro

tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].

in vivo

tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].

target

PDE5

IC 50

n/a for nortadalafil; 5 nm for tadalafil

References

[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.

Nortadalafil synthesis

Synthesis of Nortadalafil from (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE

Nortadalafil Preparation Products And Raw materials

Raw materials

Chloropretadalafil (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE

Preparation Products

Nortadalafil Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	223	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Jinan Gongchuang Pharmaceutical Technology Co., Ltd.	13287783460	3166282224@qq.com	CHINA	10	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Dayang Chem (Hangzhou) Co.,Ltd.	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hangzhou FandaChem Co.,Ltd.	55
Jinan Jianfeng Chemical Co., Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Gongchuang Pharmaceutical Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
career henan chemical co	58
SIMAGCHEM CORP	58

View Lastest Price from Nortadalafil manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-10-29	Nortadalafil 171596-36-4	US $0.00 / ASSAYS	100ASSAYS	99.99	10000	Jiangsu Monade Biological Technology Co., Ltd.
	2020-01-03	Nortadalafil 171596-36-4	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

Nortadalafil
171596-36-4
US $0.00 / ASSAYS
99.99
Jiangsu Monade Biological Technology Co., Ltd.

Nortadalafil
171596-36-4
US $7.00 / KG
99%
Career Henan Chemical Co

171596-36-4(Nortadalafil)Related Search:

Tetryzoline (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester

(1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester 2-Hydroxypropyl Nortadalafil cis-ent-Tadalafil (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylglycyl)-2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indole-3-carboxylate methyl (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester

Chloropretadalafil cis-Tadalafil D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM

Tadalafil JLEQLXGZAIAEFX-VRQJEYPFSA-N Tadalafil EP Impurity

1of4

(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Nortadalafil Tadalafil IMpurity:IMpurity C Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)- (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, N-DesMethyl Tadalafil Tadalafil IMpurity J Tadanafil N-desmethyl impurity DeMethyltadalafil N-DesMethyl Tadalafil (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil Impurity 21(N-Desmethyl Tadalafil) Nortadalafil Solution in Methanol, 100μg/mL N-demethyltadalafil (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione? (Tadalafil Impurity) (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil Impurity 21 Tetrahydropalmatine Solution, 100ppm Nortadalafil/Demethyl Tadalafil N-Desmethyl tadalafil in methanol Demethyltadalafil impurity (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione 171596-36-4 172596-36-4 Aromatics Drug Analogues Heterocycles Indole Derivatives Inhibitors Intermediates & Fine Chemicals Pharmaceuticals