AM-679
- CAS No.
- 1206880-66-1
- Chemical Name:
- AM-679
- Synonyms
- AM-679;AM-679;AM 679;(2-iodophenyl)(1-pentyl-1H-indol-3-yl)Me-thanon;(S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-Butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-1H-indol-2-yl)-2,2-dimethylpropanoic acid;3-{5-((S)-N-acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid;1H-Indole-2-propanoic acid, 5-[[(2S)-1-acetyl-2,3-dihydro-1H-indol-2-yl]methoxy]-3-[(1,1-dimethylethyl)thio]-1-[[4-(5-methoxy-2-pyrimidinyl)phenyl]methyl]-α,α-dimethyl-;5-[[(2S)-1-Acetyl-2,3-dihydro-1H-indol-2-yl]methoxy]-3-[(1,1-dimethylethyl)thio]-1-[[4-(5-methoxy-2-pyrimidinyl)phenyl]methyl]-alpha,alpha-dimethyl-1H-indole-2-propanoic acid
- CBNumber:
- CB92551767
- Molecular Formula:
- C40H44N4O5S
- Molecular Weight:
- 692.87
- MDL Number:
- MFCD20527236
- MOL File:
- 1206880-66-1.mol
- MSDS File:
- SDS
| Boiling point | 837.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 4.69±0.10(Predicted) |
| FDA UNII | 65KJ8P7M9D |
AM-679 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3169 | AM679 | 1206880-66-1 | 5mg | $305 | 2021-12-16 | Buy |
| ChemScene | CS-0935 | AM679 99.72% | 1206880-66-1 | 5mg | $312 | 2021-12-16 | Buy |
| ApexBio Technology | A3169 | AM679 | 1206880-66-1 | 10mg | $394 | 2021-12-16 | Buy |
| ChemScene | CS-0935 | AM679 99.72% | 1206880-66-1 | 10mg | $403 | 2021-12-16 | Buy |
| ApexBio Technology | A3169 | AM679 | 1206880-66-1 | 50mg | $1062 | 2021-12-16 | Buy |
AM-679 Chemical Properties,Uses,Production
Biological Activity
am679 is a topically applied and potent 5-lipoxygenase-activating protein (flap) inhibitor with an ic50 value of 2.2 nm [1] [2].flap and 5-lipoxygenase (5-lo) together convert membrane-derived arachidonic acid to the pro-inflammatory mediator leukotriene epoxide lta4. lta4 is hence rapidly converted into either ltb4 by lta4 hydrolase or ltc4 by ltc4 synthase [2].incubation with am679 for an extended time period (5 h) increased the potency of human blood against ltb4 production with an ic50 value of 53 nm. this time-dependent increase also happened with an ic50 value of 9 nm in rat blood incubated with am679 for 4 h [2].cysteinyl leukotrienes (cyslts) are known as promoters of inflammation and allergy. mouse eye infected by rsv began to show increased ocular cyslts 4 days after infection. am679 decreased the peak 6- to 8-day of ocular cyslts by more than 90%. by day 10, concentrations of cyslt for both am679-treated mouse eyes and control had almost returned to the baseline. a strong correlation between rsv and il-4 mrna had been found for human allergic conjunctivitis. 6 days after rsv infection, il-4 mrna concentrations were significantly elevated in rsv-infected mouse eyes. around 14 days, il-4 mrna concentrations were hence gradually decreased to near baseline. am679 could inhibit more than 80% of the il-4 increase resulted from rsv infection [1].
target
FLAP
References
[1]. alla musiyenko, lucia correa, nicholas stock, et al. a novel 5-lipoxygenase-activating protein inhibitor, am679, reduces inflammation in the respiratory syncytial virus-infected mouse eye. clinical and vaccine immunology, 2009, 16(11):1654-1659.
[2]. nicholas stock, christopher baccei, gretchen bain, et al. 5-lipoxygenase-activating protein inhibitors. part 2: 3-{5-((s)-1-acetyl-2,3-dihydro-1h-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1h-indol-2-yl}-2,2-dimethyl-propionic acid (am679)—a potent flap inhibitor. bioorganic & medicinal chemistry letters, 2010, 20:213-217.
AM-679 Preparation Products And Raw materials
Raw materials
Preparation Products
AM-679 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5700 | 66 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | 58 |
| Aladdin Scientific | 58 |
| China DongFan Chemical Co.,LTD | 66 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| MedChemexpress LLC | 58 |
| AdooQ BioScience, LLC | 58 |
| LETOPHARM LIMITED | 58 |
| SPIRO PHARMA | 55 |
| BOC Sciences | 65 |