OMecaMtiv Mecarbil
- CAS No.
- 873697-71-3
- Chemical Name:
- OMecaMtiv Mecarbil
- Synonyms
- CS-827;CK1827452;CK-1827452;CK 1827452O;CK1827452, >98%;mecamtiv mecarbil;OMecaMtiv Mecarbil;Omecamtiv mecarbil?, >98%;OMecaMtiv Mecarbil USP/EP/BP;CK-1827452 (OMecaMtiv Mecarbil)
- CBNumber:
- CB92561487
- Molecular Formula:
- C20H24FN5O3
- Molecular Weight:
- 401.43
- MDL Number:
- MFCD18633260
- MOL File:
- 873697-71-3.mol
- MSDS File:
- SDS
| Melting point | 180℃ |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 40.25mg/L at 25℃ |
| LogP | -0.531 |
| FDA UNII | 2M19539ERK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H370 |
| Precautionary statements | P260-P264-P270-P314-P501-P260-P264-P270-P307+P311-P321-P405-P501 |
OMecaMtiv Mecarbil price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21074 | CK-1827452 ≥98% | 873697-71-3 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 21074 | CK-1827452 ≥98% | 873697-71-3 | 5mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 21074 | CK-1827452 ≥98% | 873697-71-3 | 10mg | $301 | 2024-03-01 | Buy |
| Cayman Chemical | 21074 | CK-1827452 ≥98% | 873697-71-3 | 25mg | $661 | 2024-03-01 | Buy |
| TRC | C544000 | CK1827452 | 873697-71-3 | 10mg | $250 | 2021-12-16 | Buy |
OMecaMtiv Mecarbil Chemical Properties,Uses,Production
Description
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
In vitro
In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [
In vivo
Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
Uses
CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
Definition
ChEBI: Omecamtiv mecarbil is a member of ureas.
Biological Activity
omecamtiv mecarbil (ck-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin s1 domain but not other muscle myosins. in
target
ATPase
References
1. malik fi1, hartman jj, elias ka, morgan bp, rodriguez h, brejc k, anderson rl, sueoka sh, lee kh, finer jt, sakowicz r, baliga r, cox dr, garard m,godinez g, kawas r, kraynack e, lenzi d, lu pp, muci a, niu c, qian x, pierce dw, pokrovskii m, suehiro i, sylvester s, tochimoto t, valdez c, wang w,katori t, kass da, shen yt, vatner sf, morgans dj. cardiac myosin activation: a potential therapeutic approach for systolic heart failure. science. 2011 mar 18;331(6023):1439-43.
OMecaMtiv Mecarbil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Junyu Chemexpress.co., Ltd | +86-13723890100 | info@csjyyy.cn | China | 134 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28149 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12975 | 58 |
View Lastest Price from OMecaMtiv Mecarbil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-04-16 | Omecamtiv Mecarbil
873697-71-3
|
US $1.00 / KG | 1KG | 99% | 5000kg | Shenzhen Excellent Biotech Co., Ltd. | |
 |
2019-09-06 | OMecaMtiv Mecarbil
873697-71-3
|
US $1.00 / ASSAYS | 1ASSAYS | 95%~99% | per week:100kg | Career Henan Chemical Co |
-
- Omecamtiv Mecarbil
873697-71-3
- US $1.00 / KG
- 99%
- Shenzhen Excellent Biotech Co., Ltd.
-
- OMecaMtiv Mecarbil
873697-71-3
- US $1.00 / ASSAYS
- 95%~99%
- Career Henan Chemical Co