2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
- CAS No.
- 587870-77-7
- Chemical Name:
- 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
- Synonyms
- ABT-724 (hydrochloride);2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride;Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
- CBNumber:
- CB92609611
- Molecular Formula:
- C17H22Cl3N5
- Molecular Weight:
- 402.74908
- MDL Number:
- MFCD08703101
- MOL File:
- 587870-77-7.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
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2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A5111 | ABT-724 trihydrochloride ≥98% (HPLC) | 587870-77-7 | 25mg | $378 | 2024-03-01 | Buy |
Sigma-Aldrich | A5111 | ABT-724 trihydrochloride ≥98% (HPLC) | 587870-77-7 | 5mg | $107 | 2022-05-15 | Buy |
Cayman Chemical | 29506 | ABT-724 (hydrochloride) | 587870-77-7 | 5mg | $51 | 2024-03-01 | Buy |
Cayman Chemical | 29506 | ABT-724 (hydrochloride) | 587870-77-7 | 10mg | $87 | 2024-03-01 | Buy |
TRC | A112618 | ABT-724 trihydrochloride | 587870-77-7 | 1mg | $100 | 2021-12-16 | Buy |
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Chemical Properties,Uses,Production
Description
ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5. It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).
storage
+4°C (desiccate)
References
[1]. sarkar c, das s, chakroborty d, et al. cutting edge: stimulation of dopamine d4 receptors induce t cell quiescence by up-regulating kruppel-like factor-2 expression through inhibition of erk1/erk2 phosphorylation. j immunol, 2006, 177(11):7525-9.
[2]. melis mr, succu s, mascia ms, et al. pd-168077, a selective dopamine d4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. neurosci lett, 2005, 379(1):59-62.
[3]. sanna f, contini a, melis mr, et al. role of dopamine d4 receptors in copulatory behavior: studies with selective d4 agonists and antagonists in male rats. pharmacol biochem behav, 2015, 137:110-8.
[4]. arranz m, collier d, sodhi m, et al. association between clozapine response and allelic variation in 5-ht2a receptor gene. lancet, 1995, 346(8970):281-2.
[5]. boehmler w, carr t, thisse c, et al. d4 dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. genes brain behav, 2007, 6(2):155-66.
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
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InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
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Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3501 | 55 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |