ChemicalBook >> CAS DataBase List >>2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- structure

CAS No.: 194423-06-8

Chemical Name:: 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

Synonyms: 785;CL-387;EKB 785;CS-1630;-387785;CL-38875;WAY-EKI 785;CL-387785, >=98%;EKI-785 CL-38875;CL-387785 (EKI-785)

CBNumber:: CB92626313

Molecular Formula:: C18H13BrN4O

Molecular Weight:: 381.23

MDL Number:: MFCD02179194

MOL File:: 194423-06-8.mol

Last updated:2023-06-08 17:06:36

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2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Properties

Melting point	276 °C
Density	1.577±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL in DMSO
pka	9.84±0.43(Predicted)
form	Off-white to yellow solid.
color	White to Orange to Green
FDA UNII	B4W27J1Z8B

SAFETY

Risk and Safety Statements

HS Code	2933.59.5300

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	233100	CL-387,785 - CAS 194423-06-8 - Calbiochem	194423-06-8	1MG	$172	2024-03-01	Buy
TCI Chemical	C3575	CL-387785	194423-06-8	25MG	$166	2024-03-01	Buy
TCI Chemical	C3575	CL-387785	194423-06-8	100MG	$455	2024-03-01	Buy
Cayman Chemical	19081	CL-387785 ≥95%	194423-06-8	1mg	$37	2024-03-01	Buy
Cayman Chemical	19081	CL-387785 ≥95%	194423-06-8	5mg	$116	2024-03-01	Buy

Product number	Packaging	Price	Buy
233100	1MG	$172	Buy
C3575	25MG	$166	Buy
C3575	100MG	$455	Buy
19081	1mg	$37	Buy
19081	5mg	$116	Buy

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Chemical Properties,Uses,Production

Pharmacological activity

Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.

Description

Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC₅₀ = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC₅₀s = 31-125 nM). CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.

Uses

CL-387785 (EKI-785) is an irreversible and selective EGFR inhibitor showing activity against mutations of the receptor. Potential therapeutic against various type of cancer, including lung cancer.

Definition

ChEBI: A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group a position 6 has been replaced by a but-2-ynoyl group.

in vitro

cl-387785 covalently bound to egfr. it also specifically inhibited kinase activity of the protein, blocked egf-stimulated autophosphorylation of the receptor in cells, inhibited cell proliferation primarily in a cytostatic manner in cell lines that overexpress egf-r or c-erbb-2 [1].

in vivo

the effects of cl-387785 on tumor growth were assessed in human tumor xenografts implanted s.c. in the flanks of nude mice. cl-387785 inhibited the growth of tumors derived from a431 cells when the drug was administered i.p. or p.o.. inhibitory effects were observed within 7 days after the onset of therapy. no efficacy was observed with cl-387785 in tumors derived from cell lines that did not overexpress egf-r, including the human breast carcinoma mda-mb-435 [1].

IC 50

370 pm

References

[1] discafani cm, carroll ml, floyd mb jr, hollander ij, husain z, johnson bd, kitchen d, may mk, malo ms, minnick aa jr, nilakantan r, shen r, wang yf, wissner a, greenberger lm. irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by n-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (cl-387,785). biochem pharmacol. 1999 apr 15;57(8):917-25.

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Suppliers

Global( 85)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28098	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-24	N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide 194423-06-8	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide
194423-06-8
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- Spectrum

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-(194423-06-8)¹HNMR

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CL-387785 (EKI-785) N-(4-(3-bromophenylamino)quinazolin-6-yl)but-2-ynamide N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-2-ButynaMide CL-387785 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- CL-387785, >=98% CL-38875 EKB 785 WAY-EKI 785 EKI-785 CL-38875 CL-387 785 EKI-785; WAY-EKI 785; CL387785; CL 387785; EKI785; WAY-EKI785; EKI 785;CL-387;785 CS-1630 N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide -387785 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- USP/EP/BP CL-387785,ErbB-1,HER1,CL387785,EGFR,EKI785,inhibit,Inhibitor,CL 387785,EKI 785,Epidermal growth factor receptor 194423-06-8 Inhibitors