AZ6102
- CAS No.
- 1645286-75-4
- Chemical Name:
- AZ6102
- Synonyms
- AZ6102;CS-2332;AZ6102 >=98% (HPLC);AZ-6102;AZ6102;AZ 6102;AZ 6102,PARP,AZ-6102,Inhibitor,poly ADP ribose polymerase,inhibit,AZ6102;2-(4-(6-(cis-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one;rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-
- CBNumber:
- CB93126696
- Molecular Formula:
- C25H28N6O
- Molecular Weight:
- 428.53
- MDL Number:
- MFCD28502279
- MOL File:
- 1645286-75-4.mol
AZ6102 price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19898 | AZ 6102 ≥98% | 1645286-75-4 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 19898 | AZ 6102 ≥98% | 1645286-75-4 | 5mg | $169 | 2024-03-01 | Buy |
Cayman Chemical | 19898 | AZ 6102 ≥98% | 1645286-75-4 | 10mg | $231 | 2024-03-01 | Buy |
Cayman Chemical | 19898 | AZ 6102 ≥98% | 1645286-75-4 | 25mg | $530 | 2024-03-01 | Buy |
Tocris | 5775 | AZ6102 ≥98%(HPLC) | 1645286-75-4 | 50 | $924 | 2021-12-16 | Buy |
AZ6102 Chemical Properties,Uses,Production
Uses
AZ 6102 is a a potent TNKS1/2 inhibitor that has 100-fold selectivity against other poly(ADP-ribose) polymerase (PARP) family enzymes.
Biological Activity
az6102 is a tnks1/2 inhibitor.inhibition of the poly(adp-ribose) polymerase (parp) catalytic domain of the tankyrases (tnks1 and tnks2) is reported to inhibit the wnt pathway by increasing stabilization of axin. the canonical wnt pathway plays a critical role in adult tissue homeostasis, embryonic development, as well as cancer.
in vitro
az6102 was identified as a potent tnks1/2 inhibitor with 100-fold selectivity against other parp family enzymes including parps 1, 2, and 6. in addition, az6102 showed a 5 nm ic50 against wnt pathway in dld-1 cells [1].
in vivo
in animal study, az6102 was intravenously dosed to nude mice at 25 mg/kg, and the results showed that az6102 had a clearance of 24 ml/min·kg and a half-life of 4 h. the bioavailability of az6102 in mouse and rat was only moderate at 12% and 18%, respectively. in addition, az6102 was used as an intravenous probe compound to evaluate the in vivo effects of tnks1/2 inhibition on normal tissue and tumor xenografts, however, the results of such experiments have not be released so far [1].
IC 50
1 and 3 nm for tnks2 and tnks1, respectively
storage
Store at -20°C
References
[1] j. w. johannes, l. almeida, b. barlaam,et al.pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathways inhibitors suitable for in vivopharmacology. acs med. chem. lett. 6, 254-259 (2015).
AZ6102 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ6102 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Xiamen Work-For-World Medicine Co.,Ltd. | +undefined15921822462 | keqingyong@wfwmed.com | China | 203 | 58 |