ChemicalBook >> CAS DataBase List >>IMR-1A
IMR-1A
- CAS No.
- 331862-41-0
- Chemical Name:
- IMR-1A
- Synonyms
- IMR-1A;IMR-1A, >98%;IMR1A;IMR 1A;IMR-1A;Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite;2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
- CBNumber:
- CB93133188
- Molecular Formula:
- C13H11NO5S2
- Molecular Weight:
- 325.36
- MDL Number:
- MFCD04083080
- MOL File:
- 331862-41-0.mol
Last updated:2023-09-04 15:51:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
IMR-1A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5752 | IMR-1A 98.23% | 331862-41-0 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-5752 | IMR-1A 98.23% | 331862-41-0 | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-5752 | IMR-1A 98.23% | 331862-41-0 | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-5752 | IMR-1A 98.23% | 331862-41-0 | 100mg | $2520 | 2021-12-16 | Buy |
| CSNpharm | CSN18826 | IMR-1A | 331862-41-0 | 100mg | $2016 | 2021-12-16 | Buy |
IMR-1A Chemical Properties,Uses,Production
Biological Activity
IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.
in vivo
IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.
| Animal Model: | Male C57 BL/6 mice |
| Dosage: | 2 mg/kg (iv) and 100 mg/kg (ip) |
| Iv and ip | |
| Result: | Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration. |
target
| Target | Value | ||||
| Notch (Cell-free assay) | 0.5 μM | ||||
| Notch (Cell-free assay) | 2.9 μM(Kd) |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3501 | 55 |
IMR-1A
IMR1A;IMR 1A;IMR-1A
IMR-1A, >98%
Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
2-(2-Methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid
Notch,Inhibitor,inhibit,IMR1A,IMR-1A,IMR 1A,Drug Metabolite
331862-41-0
31862-41-0