ATI-2341
- CAS No.
- 1337878-62-2
- Chemical Name:
- ATI-2341
- Synonyms
- ATI-2341;ATI 2341;ATI2341;Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine;L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-
- CBNumber:
- CB93159454
- Molecular Formula:
- C104H178N26O25S2
- Molecular Weight:
- 2256.85
- MDL Number:
- MFCD30182359
- MOL File:
- 1337878-62-2.mol
ATI-2341 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 5795 | ATI2341 | 1337878-62-2 | 1 | $227 | 2021-12-16 | Buy |
ApexBio Technology | B7814 | ATI-2341 | 1337878-62-2 | 10mg | $614 | 2021-12-16 | Buy |
ApexBio Technology | B7814 | ATI-2341 | 1337878-62-2 | 5mg | $614 | 2021-12-16 | Buy |
ApexBio Technology | B7814 | ATI-2341 | 1337878-62-2 | 1mg | $221 | 2021-12-16 | Buy |
DC Chemicals | DC9878 | ATI-2341 >98% | 1337878-62-2 | 100mg | $1500 | 2021-12-16 | Buy |
ATI-2341 Chemical Properties,Uses,Production
Biological Activity
ati-2341 is a cxcr4 allosteric agonist.chemokine cxc-type receptor 4 (cxcr4) and its ligand cxcl12 mediate the retention of polymorphonuclear neutrophils and hematopoietic stem and progenitor cells in the bone marrow. drugs disrupting cxcl12-mediated chemoattraction of cxcr4-expressing cells are useful for hematopoietic stem and progenitor cells (hspcs) collection.
in vitro
ati-2341 could inhibit nkh477-induced camp accumulation in cxcr4-hek cells dose-dependently, but showed no effect in naive hek-293 parental cells. pretreatment of cxcr4- hek cells with pertussis toxin completely abrogated the ability of ati-2341 to inhibit camp accumulation. ati-2341 could also induce a dose-dependent increase in intracellular calcium in cells transfected with wild-type cxcr4 whereas having no effect on untransfected cells. activation of such signaling pathway by ati-2341 was dependent on a fully functional cxcr4 receptor since ati-2341 was not able to mobilize calcium in cells transfected with a cxcr4 receptor variant [1].
in vivo
ati-2341 could induce dose-dependent peritoneal recruitment of polymorphonuclear neutrophils (pmns) when i.p. administered to mice. however, when systemically administered by i.v. bolus, ati-2341 acted as an antagonist and could dose-dependently mediate release of pmns from the bone marrow of mice and cynomolgus monkeys. in addition, ati-2341-mediated release of granulocyte/macrophage progenitor cells from the bone marrow was further confirmed by colony-forming assays [1].
target
Target | Value |
CXCR4 (in CCRF-CEM cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 194 nM(EC50)
IC 50
194 nm
storage
Store at -20°C
References
[1] tchernychev b et al. discovery of a cxcr4 agonist pepducin that mobilizes bone marrow hematopoietic cells. proc natl acad sci u s a.2010 dec 21;107(51):22255-9.
ATI-2341 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |