ChemicalBook >> CAS DataBase List >>MRTX-849
MRTX-849
- CAS No.
- 2326521-71-3
- Chemical Name:
- MRTX-849
- Synonyms
- Adagrasib;2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile;MRTX-849;Adagrasib/MRTX-849;MRTX849(Adagrasib);Azvudine Impurity 23;MRTX849;MRTX-849;MRTX 849;4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR;2-PIPERAZINEACETONITRILE, 4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR;2-PIPERAZINEACETONITRILE,4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,Chemicalbook6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR
- CBNumber:
- CB94918285
- Molecular Formula:
- C32H35ClFN7O2
- Molecular Weight:
- 604.12
- MDL Number:
- MFCD32263433
- MOL File:
- 2326521-71-3.mol
Last updated:2024-05-24 17:20:43
| Boiling point | 860.2±75.0 °C(Predicted) |
|---|---|
| Density | 1.295±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO:1.0(Max Conc. mg/mL);1.7(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.31±0.40(Predicted) |
| FDA UNII | 8EOO6HQF8Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
MRTX-849 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0105265 | MRTX849 99.72% | 2326521-71-3 | 10mg | $115 | 2021-12-16 | Buy |
| ChemScene | CS-0105265 | MRTX849 99.72% | 2326521-71-3 | 25mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0105265 | MRTX849 99.72% | 2326521-71-3 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0105265 | MRTX849 99.72% | 2326521-71-3 | 100mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0105265 | MRTX849 99.72% | 2326521-71-3 | 500mg | $2150 | 2021-12-16 | Buy |
MRTX-849 Chemical Properties,Uses,Production
Uses
MRTX 849 is used as combination therapy for treatment of cancer.
brand name
Krazati
General Description
Class: non-kinase; Treatment: KRAS(G12C) NSCLC; Other name: MRTX849; Elimination half-life: 24 h; Protein binding = 98.3%
Mechanism of action
Adagrasib selectively modified mutant cysteine 12 in GDP-bound G12C and inhibited KRASdependent signaling.
Clinical Use
Adagrasib is an irreversible inhibitor of the RAS GTPase family. It is approved by the FDA for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have been identified by testing as having a KRAS (G12C) mutation.
target
Primary target: KRAS(G12C)
storage
Store at -20°C
MRTX-849 Preparation Products And Raw materials
Raw materials
Preparation Products
MRTX-849 Suppliers
Global( 153)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7154 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6708 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from MRTX-849 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-03 | MRTX-849
2326521-71-3
|
US $0.00-0.00 / g | 1g | 99% | 100000tons | Anhui Zhongda Biotechnology Co., Ltd | |
 |
2023-08-18 | MRTX-849
2326521-71-3
|
US $50.00 / kg | 1kg | 99% | 10000tons | Anhui Ruihan Technology Co., Ltd | |
 |
2023-08-13 | MRTX-849
2326521-71-3
|
US $0.00-0.00 / KG | 1KG | 98%~99% | 20 T each week | Shandong Huisheng Import & Export Co., Ltd. |
2326521-71-3(MRTX-849)Related Search:
MRTX849(Adagrasib)
Adagrasib/MRTX-849
4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR
MRTX-849
MRTX849;MRTX-849;MRTX 849
2-PIPERAZINEACETONITRILE, 4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR
2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
Adagrasib
2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile
inhibit,GDP-bound,mutant,MIA PaCa-2,MRTX-849,Adagrasib,selective,Inhibitor,MRTX 849,inactive,state,G12C,H1373,covalent,anti-tumor,KRAS,Ras,cells
2-PIPERAZINEACETONITRILE,4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,Chemicalbook6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR
2-[(S)-4-[7-(8-chloro-1-naphthyl)-2-[[(S)-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroacryloyl)-2-piperazinyl]acetonitrile
Azvudine Impurity 23
2326521-71-3
api
2326521-71-3