CARBAMATES 化学特性,用途語,生産方法
説明
The first carbamate esters to exhibit insecticidal activity
were derivatives of dithiocarbamic acid. A few
of these were contact poisons to soft-bodied insects
(aphids), whereas others, including thiram, demonstrated
antifeedant properties. In subsequent studies
with physostigmine and related carbamate compounds,
the charge of amine salts and quaternary structures was
shown to prevent their penetration through the waxy cuticle
and into the fatty nervous system of insects. Several
substituted-phenyl monomethylcarbamates were shown to
be effective contact toxins for aphids, flies, and thrips. Still
later, the oxime carbamates were discovered and shown to
be effective contact and systemic insecticides, nematocides
and/or miticides.
薬理学
Carbamate anticholinesterase agents are carbamic acid
esters that are hydrolyzed by AChE in a manner similar
to that of ACh. Carbamates have this general structure:
The clinically useful carbamates generally contain a
tertiary or quaternary amine group that can bind noncovalently
to the anionic site of the enzyme.The inhibition
of AChE by neostigmine (Prostigmin) illustrates
the general mechanism. The quaternary ammonium
group of neostigmine binds electrostatically to the anionic
site of the enzyme, thereby orienting the drug. The carbamates generally inhibit pseudo-ChE as well as true AChE, and their suicidal degradation by cholinesterases contributes importantly to terminating their duration of effect. Physostigmine (also called eserine) (Antilirium) is a tertiary amine that can inhibit AChE in the CNS, and it can be used in life-threatening
cases to treat antimuscarinic poisoning.
Pyridostigmine (Mestinon) is a quaternary ammonium
carbamate. Neostigmine and pyridostigmine also
have direct agonist activity at nicotinic receptors on
skeletal muscle. Rivastigmine (Exelon) is a carbamate
cholinesterase inhibitor with good penetration into the
brain.
代謝
The carbamates are generally broken down by hydrolysis
into the parent alcohol/phenol and a substituted carbamic
acid. The substituted carbamic acid formed is unstable and decomposes with loss of carbon dioxide to give an amine
derivative.
Numerous microorganisms in vitro have the ability
to hydrolyze promacyl either at the amide bond to form
promecarb or at the ester bond to form isothymol(16).
McDougall and Makin (17) reported that microbial degradation
accounts for seasonal declines observed in promacyl
concentrations in cattle plunge dips and that stabilization
of promacyl can be achieved by adjusting the dip wash pH
to <4.5.
CARBAMATES 上流と下流の製品情報
原材料
準備製品