マイクロクリスタリンワックス 化学特性,用途語,生産方法
定義
本品は、石油から得た常温で固体の炭化水素類の混合物で、主としてイソパラフィンからなる。
化粧品の成分用途
非水系増粘剤、結合剤、乳化安定剤、増量剤
化学的特性
Microcrystalline wax occurs as odorless and tasteless waxy lumps
or flakes containing small irregularly shaped crystals. It may vary in
color from white to yellow, amber, brown, or black depending on
the grade of material; pharmaceutical grades are usually white or
yellow.
The USP32–NF27 describes microcrystalline wax as a mixture
of straight-chain, branched-chain, and cyclic hydrocarbons,
obtained by solvent fractionation of the still-bottom fraction of
petroleum by suitable means of dewaxing or de-oiling.
調製方法
Microcrystalline wax is obtained by solvent fractionation of the
still-bottom fraction of petroleum by suitable dewaxing or deoiling.
応用例（製薬）
Microcrystalline wax is used mainly as a stiffening agent in topical
creams and ointments.
The wax is used to modify the crystal structure of other waxes
(particularly paraffin wax) present in a mixture so that changes in crystal structure, usually exhibited over a period of time, do not
occur. Microcrystalline wax also minimizes the sweating or bleeding
of oils from blends of oils and waxes. Microcrystalline wax
generally has a higher melting point than paraffin wax, and higher
viscosity when molten, thereby increasing the consistency of creams
and ointments when incorporated into such formulations.
Microcrystalline wax is also used in oral controlled-release
matrix pellet formulations for various active compounds and as
a tablet- and capsule-coating agent. In controlled-release systems,
microcrystalline wax coatings can also be used to affect the release
of drug from ion-exchange resin beads.
Microcrystalline wax is also used in confectionery, cosmetics,
and food products.
安全性
Microcrystalline wax is mainly used in topical pharmaceutical
formulations but is also used in some oral products. It is generally
regarded as a nontoxic and nonirritating material.
貯蔵
Microcrystalline wax is stable in the presence of acids, alkalis, light,
and air. The bulk material should be stored in a well-closed
container in a cool, dry place.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules;
topical and vaginal preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
マイクロクリスタリンワックス 上流と下流の製品情報
原材料
準備製品