ANTI NGFR P75R 化学特性,用途語,生産方法
使用
Monoclonal Anti-Nerve Growth Factor Receptor (NGFR p75) may be used:
- for enzyme linked immune sorbent assay (ELISA)
- immunoprecipitation, immunoblotting and immunohistochemistry
- for immunocytochemistry (acetone- or formalin-fixed, Bouin′s solution - or formalin- fixed paraffin-embedded)
- for electron- microscopy radioimmunoassay (RIA) (Kd of 7x10-10 M)
- flow cytometry
- for the inhibition of binding of NGF to the receptor
- for rossette assay
- as a cholinergic immunotoxin
一般的な説明
Recognizes the low affinity human NGFR p75 (also known as gp75
NGFR , p75
NGFR and p75
NTR). The epitope recognized by the antibody exists within the third or fourth cysteine-rich repeats of the NGFR molecule.
Biochem/physiol Actions
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.
ANTI NGFR P75R 上流と下流の製品情報
原材料
準備製品