[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid 物理性質
- 沸点 :
- 513.7±60.0 °C(Predicted)
- 比重(密度) :
- 1.27±0.1 g/cm3(Predicted)
- 蒸気圧:
- 0Pa at 25℃
- 酸解離定数(Pka):
- 4.12±0.18(Predicted)
- 外見 :
- Solid:particulate/powder
- LogP:
- 2.87
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid 価格
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[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid 化学特性,用途語,生産方法
使用
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
合成
Under a nitrogen atmosphere, N-(5-bromo-3-methyl-2-pyridinyl)-N-methylbenzamide 30.0 g was dissolved in 150 mL of tetrahydrofuran, triisopropyl borate 22.0 g was added. The reaction mixture was colled to-60 .DEGREE CELSIUS., n-butyl lithium (1.56 mol/L n-hexane solution) 69 mL was added dropwise required to between 20 minutes, and the mixture was stirred for 15 minutes at the same temperature.After raising the temperature of the reaction mixture at-20 .DEGREE CELSIUS., 390 mL of water was added dropwise, it was stirred for 30 min at room temperature,the aqueous layer was separated. The aqueous layer was fractionated and HCl 1 mol/L was added to adjust the pH at 4.5,the precipitate was collected by filtration, 6-[benzoyl(methyl)amino]-5-methyl-3-pyridinylboric acid 18.5 g was obtained as colorless solid.
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid 上流と下流の製品情報
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[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid 生産企業
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