セファドロキシル水和物
セファドロキシル水和物 物理性質
- 融点 :
- 197 °C
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,2-8°C
- 溶解性:
- 水に微溶、エタノールに微溶（96%
- 酸解離定数(Pka):
- pKa 1.38(H2O t=20±2 N2atmosphere) (Uncertain); 7.35(H2O t=20±2 N2atmosphere) (Uncertain);10.10(H2O t=20±2 N2atmosphere) (Uncertain)
- 色:
- ホワイトからオフホワイト
- BCS Class:
- 3
- InChIKey:
- NBFNMSULHIODTC-CYJZLJNKSA-N
- CAS データベース:
- 66592-87-8(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H314 |
重篤な皮膚の薬傷?眼の損傷 |
皮膚腐食性/刺激性 |
1A, B, C |
危険 |
|
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
| P310 |
ただちに医師に連絡すること。 |
|
セファドロキシル水和物 価格
もっと(9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCC235750 |
Cefadroxil |
66592-87-8 |
1g |
￥21000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCC235750 |
Cefadroxil |
66592-87-8 |
5g |
￥42300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
PHR3579 |
certified reference material, pharmaceutical secondary standard
Cefadroxil certified reference material, pharmaceutical secondary standard |
66592-87-8 |
400MG |
￥29000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
C0650000 |
European Pharmacopoeia (EP) Reference Standard
Cefadroxil European Pharmacopoeia (EP) Reference Standard |
66592-87-8 |
c0650000 |
￥19400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1097104 |
United States Pharmacopeia (USP) Reference Standard
Cefadroxil United States Pharmacopeia (USP) Reference Standard |
66592-87-8 |
200mg |
￥55400 |
2024-03-01 |
購入 |
セファドロキシル水和物 化学特性,用途語,生産方法
効能
抗生物質, 細胞壁合成阻害薬
説明
Cefadroxil has an amoxicillin-like side chain at C-7 and is orally active. There are some indications that
cefadroxil has some immunostimulant properties mediated through T-cell activation and that this is of
material assistance to patients in fighting infections. The prolonged biological half-life of cefadroxil allows
once-a-day dosage.
化学的特性
White Crystalline Solid. Soluble in chloroform, miscible with ethanol and ether, insoluble in water, and will change color when exposed to light or for a long time.
使用
Cefadroxil Monohydrate is a semi-synthetic cephalosporin antibacterial. It has been used for various community-acquired infections for which oral cephalosporins are appropriate.
定義
ChEBI: The hydrate that is the monohydrate of the cephalosporin cefadroxil.
抗菌性
Resembles closely that of cefalexin
一般的な説明
Cefadroxil is a semisynthetic first-generation β-lactam cephalosporin antibiotic derived from cefalexin with antibacterial activity. It is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis caused by susceptible bacteria.
主な応用
Cefadroxil was found by Bristol-Myers Co. in 1976. A hydroxyl group was attached to the benzene ring of cephalexin. Like amoxicillin and ampicillin, cefadroxil shows almost the same antibacterial activity spectrum as cephalexin and superior oral absorption. Its in vivo activity is four to six times greater than that of cephalexin, and its half-life in serum is twice as long.
薬物動態学
Oral absorption: >90%
C
max 250 mg oral: c. 9 mg/L after 1.2 h
500 mg oral: c. 18 mg/L after 1.2 h
Plasma half-life: 1–1.5 h
Plasma protein binding : 20%
Absorption is little affected by administration with food.
Distribution is similar to that of cefalexin. It is eliminated
unchanged by glomerular filtration and tubular secretion;
90% of the dose appears in the urine over 24 h, most in the
first 6 h, producing concentrations exceeding 500 mg/L.
薬理学
Cefadroxil has a broad spectrum of antimicrobial action; it is active with respect to Grampositive and Gram-negative microorganisms. Like all of the other drugs described above,
it acts as a bactericide by disrupting the process of restoring the membranes of bacteria.
Synonyms of this drug are bidocef, cefadril, duracef, ultracef, and others.
臨床応用
Cefadroxil (Duricef) is an orally active semisyntheticderivative of 7-ADCA, in which the 7-acyl group is the Dhydroxylphenylglycylmoiety. This compound is absorbedwell after oral administration to give plasma levels that reach75% to 80% of those of an equal dose of its close structuralanalog cephalexin. The main advantage claimed for cefadroxilis its somewhat prolonged duration of action, whichpermits once-a-day dosing. The prolonged duration of actionof this compound is related to relatively slow urinary excretionof the drug compared with other cephalosporins, butthe basis for this remains to be explained completely. Theantibacterial spectrum of action and therapeutic indications ofcefadroxil are very similar to those of cephalexin and cephradine.The D-p-hydroxyphenylglycyl isomer is much moreactive than the L-isomer.
副作用
Side effects described are those common to oral cephalosporins.
セファドロキシル水和物 上流と下流の製品情報
原材料
準備製品
セファドロキシル水和物 生産企業
Global( 262)Suppliers
セファドロキシル水和物 スペクトルデータ(1HNMR)
66592-87-8(セファドロキシル水和物)キーワード:
- 66592-87-8
- (6R,7R)-7-[(R)-2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
- CEFAMOX
- CEFADROXIL
- Cefradroxil
- P-HYDROXYCEPHALEXINE
- monohydrate,(6r-(6-alpha,7-beta(r*)))-l)acetyl)amino)-3-methyl-8-oxo
- (6R,7R)-7-[[(2R)-Amino-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate
- Baxan
- Cefa-Drops
- 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-amino(4-hydroxyphenyl)acetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-
- (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-3-methyl-8-oxo-, monohydrate, (6R-(6-alpha,7-beta(R*)))
- (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-keto-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
- (6R,7R)-7-[[(2R)-2-azanyl-2-(4-hydroxyphenyl)ethanoyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
- Cefadroxil (125 mg)I1B319935ug/mg(ai)
- Cefadroxil (200 mg)
- Cefadroxil (125 mg)
- Cefadroxill Monohydrate
- 7-[[2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- CEFADDROXIL
- Cefadroxil Monohydrate USP
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-(4-hydroxyphenyl)acetyl]aMino]-3-Methyl-8-oxo-,hydrate (1:1), (6R,7R)-
- Duracef
- MJF-11567-3
- p-Hydroxycephalexine Monohydrate
- Cefadroxil CRS
- Cefadroxil USP/EP/BP
- (6R,7R)-7-((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
- Cefadroxil MonohydrateQ: What is
Cefadroxil Monohydrate Q: What is the CAS Number of
Cefadroxil Monohydrate Q: What is the storage condition of
Cefadroxil Monohydrate
- Cefadroxil Micronised Powder
- セファドロキシル水和物
- (6R,7R)-7-[(R)-2-アミノ-2-(p-ヒドロキシフェニル)アセチルアミノ]-3-メチル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸·水和物
- セファドロキシル·1水和物
- (6R,7R)-7-[(R)-2-アミノ-2-(p-ヒドロキシフェニル)アセチルアミノ]-3-メチル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸・水和物
- セファドロキシル・1水和物