ピラゾラム
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- CAS番号.
- 39243-02-2
- 化学名:
- ピラゾラム
- 别名:
- 12-ブロモ-3-メチル-9-(ピリジン-2-イル)-2,4,5,8-テトラアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,8,10,12-ヘキサエン;ピラゾラム;8-ブロモ-1-メチル-6-(2-ピリジニル)-4H-[1,2,4]トリアゾロ[4,3-a][1,4]ベンゾジアゼピン
- 英語名:
- Pyrazolam
- 英語别名:
- Amuchin;formaty;Pirazolam;Pyrazolam;Pyrazolam 1;Pyrazolam solution;ANTIOXIDANT PUB-380;PU sealing ring PU O-ring;Custom FDA Food Grade FKM Fluorine Glue O-type Sealing Ring;FDA Food Grade O Ring HNBR Hydrogenated Acrylic Rubber Sealing Ring
- CBNumber:
- CB42742476
- 化学式:
- C16H12BrN5
- 分子量:
- 354.2
- MOL File:
- 39243-02-2.mol
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ピラゾラム 物理性質
- 融点 :
- 253-255 °C
- 沸点 :
- 544.4±60.0 °C(Predicted)
- 比重(密度) :
- 1.62±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml
- 外見 :
- A crystalline solid
- 酸解離定数(Pka):
- 2.18±0.40(Predicted)
- InChI:
- InChI=1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3
- InChIKey:
- BGRWSFIQQPVEML-UHFFFAOYSA-N
- SMILES:
- N12C(C)=NN=C1CN=C(C1=NC=CC=C1)C1=CC(Br)=CC=C12
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01FLC496513 |
8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
39243-02-2 |
250mg |
￥106300 |
2018-12-26 |
購入 |
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富士フイルム和光純薬株式会社(wako)
|
W01FLC496513 |
8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
39243-02-2 |
500mg |
￥182800 |
2018-12-26 |
購入 |
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Sigma-Aldrich Japan
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P-118 |
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material
Pyrazolam solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material |
39243-02-2 |
1ml |
￥24100 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
|
W01FLC496513 |
8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
39243-02-2 |
1g |
￥315500 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC496513 |
8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
39243-02-2 |
2.5g |
￥630300 |
2018-12-26 |
購入 |
ピラゾラム 化学特性,用途語,生産方法
説明
Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012.
Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor.
化学的特性
Pyrazolam is a benzodiazepine that has been abused recreationally. Like other benzodiazepines, pyrazolam has anxiolytic effects.
使用
Pyrazolam is a benzodiazepine with an elimination half-life of about 17 hours and no detectable metabolites in human serum and urine; thus pyrazolam may go undetected without instrumental analytical techniques.
主な応用
Pyrazolam is a designer benzodiazepine that has been sold online as a 'legal high' or 'research chemical'. Since its emergence in Europe a few years ago, pyrazolam, along with other designer benzodiazepines, have increasingly been encountered in forensic case work.
生物活性
Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine.It is most selective for the α2 and α3 subtypes of the GABAA receptor.
薬理学
Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of pyrazolam on the nervous system.The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.Pyrazolam is most selective for the α2 and α3 receptor subtypes. It is excreted by the body unchanged thus not interacting with liver enzymes like other benzodiazepines, meaning that its use in people with reduced liver function may be safer.
ピラゾラム 上流と下流の製品情報
原材料
準備製品
ピラゾラム 生産企業
Global( 71)Suppliers
39243-02-2(ピラゾラム)キーワード:
- 39243-02-2
- Pyrazolam
- 8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
- formaty
- Pyrazolam solution
- 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-bromo-1-methyl-6-(2-pyridinyl)-
- 8-Bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]be nzodiazepine
- ANTIOXIDANT PUB-380
- Pyrazolam 1
- Amuchin
- 8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]D+
- Pirazolam
- PU sealing ring PU O-ring
- High Temperature High Pressure Corrosion Resistance Abrasion Resistance O Ring VITON Low Temperature GLT Fluoro Rubber O Ring FKM Sealing Ring
- Corrosion resistant high pressure resistant PTFE FEP coated sealing ring
- VITON Low Temperature Resistant GLT Fluoro Rubber O-ring FKM Sealing Ring O-ring
- PFA Silica Gel SIL Fluorine Adhesive VITON Sealing Ring PTFE Cladding Ring
- Fluorosilicone O-ring FDA Food Grade Certification SIL Silicone Sealing Ring
- FDA Food Grade O Ring HNBR Hydrogenated Acrylic Rubber Sealing Ring
- Custom FDA Food Grade FKM Fluorine Glue O-type Sealing Ring
- 12-ブロモ-3-メチル-9-(ピリジン-2-イル)-2,4,5,8-テトラアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,8,10,12-ヘキサエン
- ピラゾラム
- 8-ブロモ-1-メチル-6-(2-ピリジニル)-4H-[1,2,4]トリアゾロ[4,3-a][1,4]ベンゾジアゼピン