PARP-1 ヒト 化学特性,用途語,生産方法
使用
PARP-1 is a nuclear enzyme that synthesizes ADP-ribose polymers from NAD
+, specifically binds Zn
2+ and DNA, and recognizes single-strand breaks in DNA. PARP1 has been used in a study to assess racial and tissue-specific cancer risk associated with polymorphism in the PARP1 gene. It has also been used in a study to investigate inhibitors of PARP-1 for potential cancer treatments.
一般的な説明
Poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the inflammation response during atherosclerosis.
Biochem/physiol Actions
PARP-1 is inactivated by cleavage into a 24kDA and 89kDA fragment by activated caspase-3 or caspase-7. This results in the decreased ability to repair DNA damage and an increase in apoptosis.
PARP-1 ヒト 上流と下流の製品情報
原材料
準備製品