コリンアルホスセラート 化学特性,用途語,生産方法
定義
本品は、ホスファチジルコリン(*)を脱アシル化して得られるものであり、次の化学式で表される。参照表示名称：ホスファチジルコリン
解説
窒素原子に4個の炭化水素基が結合してできた第四級アンモニウムイオンの塩．たとえば(CH
3)
4N
＋Cl
－．複素環内の窒素原子が隣りの炭素原子との間で二重結合をつくり，環内で第四級アンモニウム塩の構造をもつ化合物も多い．たとえばピリジニウム塩がその例である．
化粧品の成分用途
皮膚コンディショニング剤
効能
向知性薬, ムスカリン受容体作動薬
説明
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated
memory impairment. In man, it decreased and prevented scopolamine-induced
amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic
transmission by elevating the synthesis of acetylcholine.
化学的特性
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
使用
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
定義
ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
一般的な説明
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
合成
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).
コリンアルホスセラート 上流と下流の製品情報
原材料
準備製品