(+)-cis-ジルチアゼム塩酸塩 化学特性,用途語,生産方法
外観
白色, 結晶～粉末
溶解性
水に溶けやすく、エタノールに溶けにくい。
用途
カルシウム拮抗剤です。L型 電位依存性カルシウムチャネルのD部位に結 合し、細胞内へのカルシウムイオン流入を抑 制する作用を示します。
用途
カルシウム拮抗剤です。L 型
電位依存性カルシウムチャネルのD 部位に結
合し、細胞内へのカルシウムイオン流入を抑
制する作用を示します。
用途
薬理研究用。
効能
抗不整脈薬, 血圧降下薬, 冠血管拡張薬, カルシウムチャネル遮断薬
商品名
ヘルベッサー (田辺三菱製薬); ヘルベッサー (田辺三菱製薬); ヘルベッサー (田辺三菱製薬); ヘルベッサー (田辺三菱製薬)
化学的特性
Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.98. Diltiazem hydrochloride injection is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1.
使用
An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils
定義
ChEBI: Diltiazem hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. It has a role as an antihypertensive agent, a vasodilator agent and a calcium channel blocker. It contains a diltiazem(1+). It is an enantiomer of an ent-diltiazem hydrochloride.
一般的な説明
Diltiazem hydrochloride is a calcium ion cellular influx inhibitor. It was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
生物活性
Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.
Mode of action
Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.
(+)-cis-ジルチアゼム塩酸塩 上流と下流の製品情報
原材料
準備製品