レスベラトロール 化学特性,用途語,生産方法
外観
白色～うすい褐色, 結晶性粉末～粉末又は塊
定義
本品は、次の化学式で表されるスチルベン誘導体である。
溶解性
エタノール及びアセトンに溶け、水にほとんど溶けない。
用途
阻害剤。
化粧品の成分用途
皮膚保護剤、酸化防止剤
使用上の注意
不活性ガス封入
化学的特性
Off-White to Tan Powder
定義
ChEBI:Resveratrol is a stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy
groups. It has a role as a phytoalexin, an antioxidant, a
glioma-associated oncogene inhibitor and a geroprotector. It is a
stilbenol, a polyphenol and a member of resorcinols.
説明
Resveratrol, a non-flavonoid polyphenolic compound, is widely found in the skin of red grapes, nuts, berries,
Polygonum cuspidatum root, etc. It is reportedly known to exhibit pharmacological properties including anti-cancer, anti-inflammatory, antioxidant, neuroprotectant, anti-atherogenic property and reduces the synthesis of pro-atherosclerotic substances.
生物活性
A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC 50 = 23 μ M) and displays mixed agonist/antagonist actions at ER α and ER β estrogen receptors. Converted into the anticancer agent piceatannol (4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol ) by cytochrome P450 1B1
作用機序
Resveratrol can be found in the skins and seeds of grapes and in peanuts. It has demonstrated potent antioxidant, anti-inflammatory, and anti-proliferative activities. Topical application of resveratrol in mice demonstrated photoprotection by significantly decreasing UVB-mediated generation of hydrogen peroxide and infiltration of leukocytes. Its antiproliferative properties are related to the inhibition of cellular events associated with tumor initiation, promotion, and progression, and the triggering of apoptosis in tumor cells.
レスベラトロール 上流と下流の製品情報
原材料
準備製品