5-(アミノスルホニル)-2-メトキシ安息香酸
5-(アミノスルホニル)-2-メトキシ安息香酸 物理性質
- 融点 :
- 220 °C
- 沸点 :
- 482.5±55.0 °C(Predicted)
- 比重(密度) :
- 1.492±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Room Temperature
- 溶解性:
- DMSO（微量）、メタノール（微量）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 3.56±0.10(Predicted)
- 色:
- ホワイトからオフホワイト
- CAS データベース:
- 22117-85-7(CAS DataBase Reference)
5-(アミノスルホニル)-2-メトキシ安息香酸 価格
もっと(19)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAB23698 |
2-メトキシ-5-スルファモイル安息香酸
2-Methoxy-5-sulfamoylbenzoic Acid |
22117-85-7 |
10g |
￥12210 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAB23698 |
2-メトキシ-5-スルファモイル安息香酸
2-Methoxy-5-sulfamoylbenzoic Acid |
22117-85-7 |
50g |
￥38040 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0232-7607 |
2-メトキシ-5-スルファモイル安息香酸 97.0+%
2-Methoxy-5-sulfamoylbenzoic Acid 97.0+% |
22117-85-7 |
5g |
￥5700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCM326640 |
2-メトキシ-5-スルファモイル安息香酸
2-Methoxy-5-sulfamoylbenzoic Acid |
22117-85-7 |
1g |
￥47400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0232-7607 |
2-メトキシ-5-スルファモイル安息香酸 97.0+%
2-Methoxy-5-sulfamoylbenzoic Acid 97.0+% |
22117-85-7 |
25g |
￥17000 |
2024-03-01 |
購入 |
5-(アミノスルホニル)-2-メトキシ安息香酸 化学特性,用途語,生産方法
外観
白色～微黄色、結晶性粉末～粉末
用途
有機合成原料。
使用
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
製造方法
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
5-(アミノスルホニル)-2-メトキシ安息香酸 上流と下流の製品情報
原材料
準備製品
5-(アミノスルホニル)-2-メトキシ安息香酸 生産企業
Global( 165)Suppliers
22117-85-7(5-(アミノスルホニル)-2-メトキシ安息香酸)キーワード:
- 22117-85-7
- 2-METHOXY-5-SULFAMOYLBENZOIC ACID
- 2-METHOXY-5-SULFONYLBENZOIC ACID
- 2-METHOXY-5-SULPHAMOYLBENZOIC ACID
- 3-CARBOXY-4-METHOXY-BENZENE SULFONAMIDE
- 2-Methoxy-5-Sufamoyl Benzoic Acid
- 5-Aminosulfonyl-2-Methoxybenzoic Acid
- 5-sulphamoyl-o-anisic acid
- 5-(Aminosulphonyl)-2-methoxybenzoic acid
- 2-METHOXY-5-SULFONAMIDOBENZOIC ACID
- 3-Carboxy-4-methoxybenzenesulphonamide
- 2-Methoxy-5-sulfaMidobenzoic Acid
- 5-SulfaMoyl-o-anisic Acid
- 2-METHOXY-5-SULFAMOYLBENZOIC ACIDSULPIRIDE
- Sulpiride IMpurity D
- 3-Carboxy-4-methoxybenzenesulphonamide, 5-(Aminosulphonyl)-o-anisic acid
- Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-
- carbazole2-Methoxy-5-sulfamoylbenzoic acid
- Sulpiride Impurity D(EP)
- 6-methoxy-3-sulfonyl-1-cyclohexa-1,5-dienecarboxylic acid
- Sulpiride Impurity 4（Sulpiride EP Impurity D）
- Sulpiride EP Impurity D
- Levosulpiride - EP Impurity D
- 5-[(Aminoperoxy)thio]-2-methoxybenzoic Acid
- 2-Methoxy-5-sulfamoylbenzoicaci
- Sulpride Impurity D
- 2-メトキシ-5-スルファモイル安息香酸
- 5-(アミノスルホニル)-2-メトキシ安息香酸