3‐シアノ‐5‐フルオロベンズアルデヒド
3‐シアノ‐5‐フルオロベンズアルデヒド 物理性質
- 沸点 :
- 205℃
- 比重(密度) :
- 1.25
- 闪点 :
- 77℃
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 外見 :
- solid
- 色:
- Off-white
3‐シアノ‐5‐フルオロベンズアルデヒド 価格
もっと(1)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
関東化学株式会社(KANTO)
|
07090-62 |
３‐シアノ‐５‐フルオロベンズアルデヒド >97.0%(GC)
3‐Cyano‐5‐fluorobenzaldehyde >97.0%(GC) |
1003708-42-6 |
1g |
￥16000 |
2024-03-01 |
購入 |
3‐シアノ‐5‐フルオロベンズアルデヒド 化学特性,用途語,生産方法
使用
3-Fluoro-5-formylbenzonitrile is benzaldehyde based building block used as a reactant in catalyst-free synthesis of N-β-hydroxyethyl pyrroles and indoles via a domino [3+2] cycloaddition and ring-opening aromatization process.
主な応用
3-FLUORO-5-FORMYLBENZONITRILE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
合成
3 -fluoro-5 -formylbenzonitrile : A solution of 3 -bromo-5 -fluorobenzonitrile(5.00 g, 25.0 mmol) in dry THF (25 mL) was cooled to 0 °C and 2M iPrMgCl (15.0 mL, 30.0 mmol) in THF was added dropwise over 5 minutes. The mixture was stirred at 0 °C for 15 minutes then at ambient temperature for 1 hour. The mixture was cooled to 0 °C and dry DMF (5.81 mL, 75.0 mmol) was added. The mixture was stirred for 17 hours during which time the temperature reached ambient temperature after 2 hours. The mixture was added to ice water (150 mL) and Et20 (100 mL). The biphasic mixture was stirred and treated with 6M HC1 to aqueous pH=3. The organic layer was removed and the aqueous layer extracted with Et20 (2X). The combined Et20 fractions were washed with saturated NaCl and dried over MgS04/activated carbon. The dried solution was filtered through a S1O2 plug eluting with Et20. The filtrate was concentrated to give the title compound as a yellow solid that was dried in vacuum (3.68 g, 99percent). 1H NMR (CDC13) δ 10.0 (s, 1H), 8.00 (s, 1H), 7.81-7.86 (m, 1H), 7.62-7.67 (m, 1H).
3‐シアノ‐5‐フルオロベンズアルデヒド 上流と下流の製品情報
原材料
準備製品
3‐シアノ‐5‐フルオロベンズアルデヒド 生産企業
Global( 119)Suppliers
- 1003708-42-6
- 3-FLUORO-5-FORMYLBENZONITRILE
- Benzonitrile, 3-fluoro-5-formyl-
- 4-Chloro-4-(trifluoromethyl)acetophenone
- 3‐シアノ‐5‐フルオロベンズアルデヒド