Y-27632二塩酸塩 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
使用
A cell permeable inhibitor of ROCK-1 and ROCK-2
一般的な説明
Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.
Y-27632二塩酸塩 上流と下流の製品情報
原材料
準備製品