MK-571 ナトリウム塩 水和物
MK-571 ナトリウム塩 水和物 物理性質
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- H2O: 可溶15mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
MK-571 ナトリウム塩 水和物 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
M7571 |
MK-571 ナトリウム塩 水和物 ≥95% (HPLC)
MK-571 sodium salt hydrate ≥95% (HPLC) |
115103-85-0 |
25mg |
￥89300 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
M7571 |
MK-571 ナトリウム塩 水和物 ≥95% (HPLC)
MK-571 sodium salt hydrate ≥95% (HPLC) |
115103-85-0 |
5mg |
￥29300 |
2018-12-25 |
購入 |
MK-571 ナトリウム塩 水和物 化学特性,用途語,生産方法
使用
MK-571 sodium salt hydrate has been used:
- as an efflux inhibitor for monitoring multidrug resistance protein (MRP)-function and to avoid redundancy of other transporters
- to assess its effect on cell proliferation and 2D-migration in vitro in various cell lines of glioblastoma multiforme (GBM)
- as multidrug resistance (MDR) transporter inhibitor to study its effects in ovarian cancer cells
- as specific inhibitors of ABCC1/2 to investigate transport, toxicity, flow cytometry and arsenic efflux
Biochem/physiol Actions
MK 571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G-protein coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK 571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to overcome acquired arsenic tolerance.
MK-571 ナトリウム塩 水和物 上流と下流の製品情報
原材料
準備製品
MK-571 ナトリウム塩 水和物 生産企業
Global( 60)Suppliers
MK-571 ナトリウム塩 水和物 スペクトルデータ(MS)
- 115103-85-0
- MK-571 SODIUM HYDRATE
- Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-
- 5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid sodium salt hydrate
- MK-571 sodium salt hydrate
- (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid sodium salt
- MK-571 Sodium (L-660711)
- MK-571 sodium saL
- L-660;711;MK571;MK 571;L660711;L-660711
- L-660
- 711
- L-660;711;MK571;MK 571;L660711;L-660711;L-660711 SODIUM SALT;MK571 SODIUM SALT;MK 571 SODIUM SALT;L660711 SODIUM SALT;L 660711 SODIUM SALT;MK-571 SODIUM SALT
- Verlukast sodium
- MK-571 Sodium
- Sodium (E)-3-(((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoate
- Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)
- (E)-3-3-2-(7-Chloro-quinolin-2-yl)ethenylphenyl3-(dimethylamino)-3-oxo-propylthiomethylthiopropanoic acid sodium salt
- MK-571 ナトリウム塩 水和物