KP 103 manufacturers and suppliers

KP 103 suppliers

Properties

Melting point:: 192-195°C

Boiling point:: 512.2±60.0 °C(Predicted)

Density: 1.26±0.1 g/cm3(Predicted)

storage temp.: -20°C

solubility: Chloroform (Slightly), Methanol (Slightly)

pka: 12.11±0.29(Predicted)

form: powder

color: white to beige

optical activity: [α]/D -85 to -95°, c = 1 in chloroform

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P308+P313

Use

In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC80 =0.125 μg/mL) and Trichophyton rubrum (MIC80 =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine.

You can find KP 103 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.