Mizolastine manufacturers and suppliers

Mizolastine suppliers

Properties

Melting point:: 217°

Density: 1.34±0.1 g/cm3(Predicted)

storage temp.: Refrigerator

solubility: Chloroform (Slightly, Heated), DMSO, Methanol (Slightly, Heated)

form: Solid

pka: 9.73±0.40(Predicted)

color: White

Merck: 14,6221

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H312-H332

Precautionary statements: P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501

RTECS: UW7481284

HS Code: 2933.39.9200

Use

Mizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzimidazole by successive condensations of appropriate amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors (but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal occupancy of brain receptors, and therefore does not elicit any sedative effects. Moreover, Mizolastine does not produce cardiac rhythm disorders which have been associated with certain non-sedating antihistamines in humans.

You can find Mizolastine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.