Udenafil manufacturers and suppliers

Udenafil suppliers

Udenafil

CAS:: 268203-93-6

MF:: C25H36N6O4S

MW:: 516.66

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Properties

Melting point:: 152-159°C

Boiling point:: 697.0±65.0 °C(Predicted)

Density: 1.35

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

solubility: Chloroform (Slightly), Methanol (Sparingly)

form: Solid

pka: 11.07±0.50(Predicted)

color: White to Pale Beige

Safety Information

Use

Udenafil is the fourth in a class of drugs targeting the inhibition of the enzyme phosphodiesterase 5 (PDE5) for the treatment of erectile dysfunction. Inhibition of PDE5 results in the increase in endogenous cyclic guanosine monophosphate (cGMP) concentrations in the penile corpus cavernosum. cGMP induces smooth muscle cell relaxation and subsequent increased blood flow leading to a sustainable erection. Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25nM and a comparable selectivity profile as sildenafil for the other PDEs. Unlike tadalafil, it does not inhibit PDE11, which has been implicated in myalgia and testicular toxicity. Furthermore, udenafil produced up to a 91% vaginal penetration success rate and up to a 67% intercourse completion rate compared to a 29% completion rate by placebo. Overall patient satisfaction, measured by a standard global assessment question, was 86% compared to only 26% in the placebo group. The most frequently recorded adverse events were mild-to-moderate facial flushing and headache.

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