10-Propargyl-10-deazaaminopterin
|
- $45 - $4400
- Product name: 10-Propargyl-10-deazaaminopterin
- CAS: 146464-95-1
- MF: C23H23N7O5
- MW: 477.47
- EINECS:
- MDL Number:MFCD00920897
- Synonyms:N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid;10-Propargyl-10-deazaaminopterin;L-Glutamic acid, N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-;Unii-A8Q8I19Q20;FOLOTYN PRALATREXATE;N-(4-{1-[(2,4-diaMinopteridin-6-yl)Methyl]but-3-yn-1-yl}benzoyl)-L-glutaMic acid;N-[4-[1-[(2,4-DiaMino-6-pteridinyl)Methyl]-3-butyn-1-yl]benzoyl]-L-glutaMic Acid;(2S)-2-(4-(1-(2,4-diaMinopteridin-6-yl)pent-4-yn-2-yl)benzaMido)pentanedioic acid
29 prices
Selected condition：
Brand
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TCI Chemical
- TRC
Package
- 10MG
- 10mM(in 1mL DMSO)
- 5MG
- 25MG
- 50mg
- 100MG
- 250mg
- 1g
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging5MG
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging25MG
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product number10627
- Product description10-Propargyl-10-deazaaminopterin 95%
- Packaging100MG
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005288
- Product descriptionPRALATREXATE 95.00%
- Packaging10MG
- Price$2000
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005288
- Product descriptionPRALATREXATE 95.00%
- Packaging25MG
- Price$4400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging10mM(in 1mL DMSO)
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging10mg
- Price$224
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4350
- Product descriptionPralatrexate
- Packaging50mg
- Price$679
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging10mg
- Price$364
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging50mg
- Price$455
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23689
- Product descriptionPralatrexate ≥98%
- Packaging100mg
- Price$546
- Updated2024-03-01
- Buy
- ManufacturerChem-Impex
- Product number38204
- Product descriptionPralatrexate,98%(HPLC) 98%(HPLC)
- Packaging25MG
- Price$169.12
- Updated2021-12-16
- Buy
- ManufacturerChem-Impex
- Product number38204
- Product descriptionPralatrexate,98%(HPLC) 98%(HPLC)
- Packaging100MG
- Price$532
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0504
- Product descriptionPralatrexate 99.23%
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 5MG | $45 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 25MG | $145 | 2021-12-16 | Buy |
| ACHEMBLOCK | 10627 | 10-Propargyl-10-deazaaminopterin 95% | 100MG | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005288 | PRALATREXATE 95.00% | 10MG | $2000 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005288 | PRALATREXATE 95.00% | 25MG | $4400 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 10mM(in 1mL DMSO) | $182 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 10mg | $224 | 2021-12-16 | Buy |
| ApexBio Technology | A4350 | Pralatrexate | 50mg | $679 | 2021-12-16 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 10mg | $364 | 2024-03-01 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 50mg | $455 | 2024-03-01 | Buy |
| Cayman Chemical | 23689 | Pralatrexate ≥98% | 100mg | $546 | 2024-03-01 | Buy |
| Chem-Impex | 38204 | Pralatrexate,98%(HPLC) 98%(HPLC) | 25MG | $169.12 | 2021-12-16 | Buy |
| Chem-Impex | 38204 | Pralatrexate,98%(HPLC) 98%(HPLC) | 100MG | $532 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0504 | Pralatrexate 99.23% | 50mg | $250 | 2021-12-16 | Buy |
Properties
Melting point :215 °C(dec.)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
Water Solubility :Insoluble in water
solubility :≥23.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka :3.53±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Pralatrexate, an injectable DHFR inhibitor, was launched for the treatment of patients with relapsed or refractory PTCL. PTCL is an aggressive form of non-Hodgkin’s lymphoma (NHL) characterized by the proliferation of abnormal T-lymphocytes that circulate in the peripheral bloodstream. The inhibition of the folate enzymes DHFR and thymidylate synthase is a well-validated method of cancer treatment. In vitro, pralatrexate is slightly less potent than MTX in inhibiting DHFR derived from murine leukemia L1210 cells (Ki = 18.2 pM vs. 5.75 pM) and human leukemia CCRF-CEM cells (Ki = 13.4 pM vs. 5.4 pM). However, it is transported into both types of cells with 10-fold higher efficiency than MTX, thereby providing a more potent inhibition of cell growth as compared with MTX. In vivo, intraperitonally administered pralatrexate at 60 mg/ kg twice weekly for three or four doses caused complete lymphoma regressions in 89, 56, and 30% of HT, RL, and SKI-DLBCL-1 xenografted mice, respectively, whereas a similar dosing of MTX at 40 mg/kg twice weekly did not produce complete regression. The posttreatment tumor diameter was also smaller in pralatrexate-treated animals.Related product price
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Suppliers and manufacturers
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
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Lianyungang happen teng technology co., LTD
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BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
