3-CYANO-7-ETHOXYCOUMARIN
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- $39 - $1000
- Product name: 3-CYANO-7-ETHOXYCOUMARIN
- CAS: 117620-77-6
- MF: C12H9NO3
- MW: 215.2
- EINECS:200-562-0
- MDL Number:MFCD00467359
- Synonyms:7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile;7-ETHOXYCOUMARIN-3-CARBONITRILE;3-CYANO-7-ETHOXYCOUMARIN;2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI);3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*;7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile;CEC [3-Cyano-7-ethoxycoumarin] *CAS 117620-77-6*;CEC [3-Cyano-7-ethoxycoumarin
37 prices
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Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- SynQuest Laboratories
- Tocris
- TRC
- Usbiological
Package
- 50
- 10
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberCDX-C0092-M020
- Product description3-Cyano-7-ethoxycoumarin ≥99%(HPLC)
- Packaging20mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2868AA
- Product description7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile
- Packaging50mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2868AA
- Product description7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile
- Packaging100mg
- Price$215
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging25mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging50mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging100mg
- Price$209
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging250mg
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA743956
- Product description3-Cyano-7-ethoxycoumarin 98+%
- Packaging1g
- Price$991
- Updated2021-12-16
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- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0023436
- Product description3-CYANO-7-ETHOXYCOUMARIN 95.00%
- Packaging1G
- Price$333.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7714
- Product description3-Cyano-7-ethoxycoumarin
- Packaging10mg
- Price$87
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberB7714
- Product description3-Cyano-7-ethoxycoumarin
- Packaging50mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberOR351016
- Product description3-Cyano-7-ethoxycoumarin
- Packaging250mg
- Price$269
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545905
- Product description3-Cyano-7-ethoxycoumarin >98%
- Packaging10mg
- Price$198.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545905
- Product description3-Cyano-7-ethoxycoumarin >98%
- Packaging50mg
- Price$554.2
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC67318
- Product description3-Cyano-7-ethoxycoumarin
- Packaging50mg
- Price$75
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-C0092-M020 | 3-Cyano-7-ethoxycoumarin ≥99%(HPLC) | 20mg | $171 | 2021-12-16 | Buy |
| AK Scientific | 2868AA | 7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile | 50mg | $150 | 2021-12-16 | Buy |
| AK Scientific | 2868AA | 7-Ethoxy-2-oxo-2H-chromene-3-carbonitrile | 100mg | $215 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 10mg | $39 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 25mg | $70 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 50mg | $118 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 100mg | $209 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 250mg | $253 | 2021-12-16 | Buy |
| Ambeed | A743956 | 3-Cyano-7-ethoxycoumarin 98+% | 1g | $991 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0023436 | 3-CYANO-7-ETHOXYCOUMARIN 95.00% | 1G | $333.9 | 2021-12-16 | Buy |
| ApexBio Technology | B7714 | 3-Cyano-7-ethoxycoumarin | 10mg | $87 | 2021-12-16 | Buy |
| ApexBio Technology | B7714 | 3-Cyano-7-ethoxycoumarin | 50mg | $260 | 2021-12-16 | Buy |
| Apolloscientific | OR351016 | 3-Cyano-7-ethoxycoumarin | 250mg | $269 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545905 | 3-Cyano-7-ethoxycoumarin >98% | 10mg | $198.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545905 | 3-Cyano-7-ethoxycoumarin >98% | 50mg | $554.2 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC67318 | 3-Cyano-7-ethoxycoumarin | 50mg | $75 | 2021-12-16 | Buy |
Properties
Melting point :210-212°C
Boiling point :396.8±42.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :Solid
color :yellow to orange
λmax :356 nm (Buffer pH7); 355 nm(MeOH)
Biological Applications :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
Boiling point :396.8±42.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :Solid
color :yellow to orange
λmax :356 nm (Buffer pH7); 355 nm(MeOH)
Biological Applications :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
Safety Information
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Description
This reagent is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. The product of the reaction is the fluorescent compound 3-cyano-7-hydroxycoumarin (Product No. C 2737). This property has been utilized to determine the activity of CYP1A by measuring the rate of dealkylation of 3-Cyano-7-ethoxycoumarin to this fluorescent product. Fluorescence of 3-cyano-7-hydroxycoumarin occurs at neutral pH with excitation and emission at 408 and 450 nm, respectively. Fluorescent reaction product detection is at least 50-fold more sensitive than that of the product of alkyl resorufin oxidation because of greater rate of turnover of 3-Cyano-7-ethoxycoumarin. The ability to continuously monitor the enzyme reaction at pH 7 is derived from the lower pKa of the 3-cyano-7- hydroxycoumarin product compared to that for 7-ethoxycoumarin. 3-Cyano-7-ethoxycoumarin is a suitable substrate for three of the five principal cytochrome P450 drug metabolizing enzymes, CYP1A1, CYP1A2, CYP2C9, and CYP2C19. It has been used to measure cytochrome P450 mixed-function monooxygenases in rat hepatic microsomal preparations as well as in isolated rat hepatocytes. It was part of a study to examine the expression of CYP2B6 in human liver microsomes, and has been used to characterize Clara and type II cells from rat lung.More related product prices
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$39-1000
