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ChemicalBook >> CAS DataBase List >> 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole price.
  • $32 - $1871.1
  • Product name: 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
  • CAS: 303727-31-3
  • MF: C20H14ClN3O
  • MW: 347.8
  • EINECS:
  • MDL Number:MFCD12828750
  • Synonyms:2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole;L-779450;2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-iMidazole;Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-;2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol;2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(pyridin-4-yl)-1H-iMidazole
Price38 Properties Safety Information Description
38 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberZ4580
  • Product description2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol
  • Packaging5mg
  • Price$209
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA986611
  • Product descriptionL-779450 98+%
  • Packaging5mg
  • Price$293
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA986611
  • Product descriptionL-779450 98+%
  • Packaging10mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA986611
  • Product descriptionL-779450 98+%
  • Packaging25mg
  • Price$494
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA986611
  • Product descriptionL-779450 98+%
  • Packaging50mg
  • Price$641
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA986611
  • Product descriptionL-779450 98+%
  • Packaging100mg
  • Price$833
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000148
  • Product descriptionL-779,450 95.00%
  • Packaging10MG
  • Price$739.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000148
  • Product descriptionL-779,450 95.00%
  • Packaging100MG
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7307
  • Product descriptionL-779,450
  • Packaging50mg
  • Price$882
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7307
  • Product descriptionL-779,450
  • Packaging100mg
  • Price$1496
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0240
  • Product descriptionL-779450
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0240
  • Product descriptionL-779450
  • Packaging25mg
  • Price$428
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0240
  • Product descriptionL-779450
  • Packaging50mg
  • Price$798
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS702540
  • Product descriptionL-779450
  • Packaging100mg
  • Price$1058
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17807
  • Product descriptionL-779,450 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17807
  • Product descriptionL-779,450 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Z4580 2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol 5mg $209 2021-12-16 Buy
Ambeed A986611 L-779450 98+% 5mg $293 2021-12-16 Buy
Ambeed A986611 L-779450 98+% 10mg $380 2021-12-16 Buy
Ambeed A986611 L-779450 98+% 25mg $494 2021-12-16 Buy
Ambeed A986611 L-779450 98+% 50mg $641 2021-12-16 Buy
Ambeed A986611 L-779450 98+% 100mg $833 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000148 L-779,450 95.00% 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000148 L-779,450 95.00% 100MG $1871.1 2021-12-16 Buy
ApexBio Technology B7307 L-779,450 50mg $882 2021-12-16 Buy
ApexBio Technology B7307 L-779,450 100mg $1496 2021-12-16 Buy
Apolloscientific BISN0240 L-779450 5mg $138 2021-12-16 Buy
Apolloscientific BISN0240 L-779450 25mg $428 2021-12-16 Buy
Apolloscientific BISN0240 L-779450 50mg $798 2021-12-16 Buy
Arctom AS702540 L-779450 100mg $1058 2021-12-16 Buy
Cayman Chemical 17807 L-779,450 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 17807 L-779,450 ≥98% 5mg $100 2024-03-01 Buy
Next Last

Properties

Boiling point :579.8±50.0 °C(Predicted)
Density :1.335±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM) form :Powder
pka :8.09±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM; Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38α, GSK3β, and Lck, respectively. It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in these cells.

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Suppliers and manufacturers

career henan chemical co
2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol
$1.00 /1KG
2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol CAS:303727-31-3
Dideu Industries Group Limited
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
$1.10 /1g
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole CAS:303727-31-3
ATK CHEMICAL COMPANY LIMITED
Hubei Jusheng Technology Co.,Ltd.
Alchem Pharmtech,Inc.
TargetMol Chemicals Inc.
ANHUI WITOP BIOTECH CO., LTD
Finetech Industry Limited
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited