IMD-0354
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- $33 - $1528
- Product name: IMD-0354
- CAS: 978-62-1
- MF: C15H8ClF6NO2
- MW: 383.67
- EINECS:
- MDL Number:MFCD00218820
- Synonyms:Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
40 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2473AH
- Product descriptionIMD0354
- Packaging1g
- Price$1269
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ65132
- Product descriptionIKK-2 Inhibitor V
- Packaging10mg
- Price$156
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging10mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging50mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging100mg
- Price$392
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging250mg
- Price$593
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging1g
- Price$1528
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000857
- Product descriptionIMD-0354 95.00%
- Packaging1MG
- Price$140.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000857
- Product descriptionIMD-0354 95.00%
- Packaging10MG
- Price$697.34
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000857
- Product descriptionIMD-0354 95.00%
- Packaging50MG
- Price$1170.31
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1587
- Product descriptionIMD0354
- Packaging10mg
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS487423
- Product descriptionIMD-0354 ≥98%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS487423
- Product descriptionIMD-0354 ≥98%
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS487423
- Product descriptionIMD-0354 ≥98%
- Packaging10mg
- Price$86
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2473AH | IMD0354 | 1g | $1269 | 2021-12-16 | Buy |
| Alfa Aesar | J65132 | IKK-2 Inhibitor V | 10mg | $156 | 2023-06-20 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 1mg | $33 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 5mg | $59 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 10mg | $87 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 50mg | $202 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 100mg | $392 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 250mg | $593 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 1g | $1528 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000857 | IMD-0354 95.00% | 1MG | $140.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000857 | IMD-0354 95.00% | 10MG | $697.34 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000857 | IMD-0354 95.00% | 50MG | $1170.31 | 2021-12-16 | Buy |
| ApexBio Technology | B1587 | IMD0354 | 10mg | $77 | 2021-12-16 | Buy |
| Arctom | AS487423 | IMD-0354 ≥98% | 1mg | $33 | 2021-12-16 | Buy |
| Arctom | AS487423 | IMD-0354 ≥98% | 5mg | $58 | 2021-12-16 | Buy |
| Arctom | AS487423 | IMD-0354 ≥98% | 10mg | $86 | 2021-12-16 | Buy |
Properties
Boiling point :323.1±42.0 °C(Predicted)
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
form :White solid
pka :7.61±0.43(Predicted)
Sensitive :Light Sensitive
CAS DataBase Reference :978-62-1
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
form :White solid
pka :7.61±0.43(Predicted)
Sensitive :Light Sensitive
CAS DataBase Reference :978-62-1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.More related product prices
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