MCC950
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- $58 - $1416
- Product name: MCC950
- CAS: 210826-40-7
- MF: C20H24N2O5S
- MW: 404.48
- EINECS:604-604-1
- MDL Number:MFCD28900720
- Synonyms:N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamid;MCC950;N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide;N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamChemicalbookide;2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-;1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea;MCC950 (MCC-950;CS-2292
27 prices
Selected condition：
Brand
- Acints
- Advanced Chemicals Intermediatesced Chemicals Intermediates
- AK Scientific
- Biorbyt Ltd
- Cayman Chemical
- Crysdot
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAcints
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAcints
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging10mg
- Price$94.25
- Updated2021-12-16
- Buy
- ManufacturerAcints
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging25mg
- Price$239.25
- Updated2021-12-16
- Buy
- ManufacturerAcints
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging50mg
- Price$413.25
- Updated2021-12-16
- Buy
- ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging10mg
- Price$94.25
- Updated2021-12-16
- Buy
- ManufacturerAdvanced Chemicals Intermediatesced Chemicals Intermediates
- Product numberABI-06E-001
- Product descriptionN-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+
- Packaging50mg
- Price$413.25
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4160CR
- Product descriptionN-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
- Packaging1mg
- Price$187
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4160CR
- Product descriptionN-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
- Packaging5mg
- Price$472
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4160CR
- Product descriptionN-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
- Packaging10mg
- Price$758
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4160CR
- Product descriptionN-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide
- Packaging25mg
- Price$1416
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611595
- Product descriptionMCC950
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611595
- Product descriptionMCC950
- Packaging250mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611595
- Product descriptionMCC950
- Packaging1g
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17510
- Product descriptionMCC950 ≥98%
- Packaging1mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17510
- Product descriptionMCC950 ≥98%
- Packaging5mg
- Price$336
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acints | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 5mg | $58 | 2021-12-16 | Buy |
| Acints | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 10mg | $94.25 | 2021-12-16 | Buy |
| Acints | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 25mg | $239.25 | 2021-12-16 | Buy |
| Acints | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 50mg | $413.25 | 2021-12-16 | Buy |
| Advanced Chemicals Intermediatesced Chemicals Intermediates | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 5mg | $58 | 2021-12-16 | Buy |
| Advanced Chemicals Intermediatesced Chemicals Intermediates | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 10mg | $94.25 | 2021-12-16 | Buy |
| Advanced Chemicals Intermediatesced Chemicals Intermediates | ABI-06E-001 | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide 95%+ | 50mg | $413.25 | 2021-12-16 | Buy |
| AK Scientific | 4160CR | N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | 1mg | $187 | 2021-12-16 | Buy |
| AK Scientific | 4160CR | N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | 5mg | $472 | 2021-12-16 | Buy |
| AK Scientific | 4160CR | N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | 10mg | $758 | 2021-12-16 | Buy |
| AK Scientific | 4160CR | N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | 25mg | $1416 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611595 | MCC950 | 100mg | $414.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611595 | MCC950 | 250mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611595 | MCC950 | 1g | $1208.7 | 2021-12-16 | Buy |
| Cayman Chemical | 17510 | MCC950 ≥98% | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 17510 | MCC950 ≥98% | 5mg | $336 | 2024-03-01 | Buy |
Properties
Melting point :239 °C
Density :1.396±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
form :solid
pka :4.74±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Density :1.396±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
form :solid
pka :4.74±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Safety Information
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Description
NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer’s disease, and atherosclerosis. MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM). It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin. MCC-950 is active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome. It is also active in ex vivo samples from individuals with Muckle-Wells syndrome.Related product price
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