| | 474645-27-7 Basic information More.. |
| Product Name: | MonoMethyl auristatin E | | Synonyms: | MonoMethyl auristatin E(MMAE, vedotin);HM-297C-22;MonoMethyl auristatin E;Monomethyl auristatin E, >=98%;MMAE(Monomethyl auristatin E);(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide;[3H]-Vedotin;(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy | | CAS: | 474645-27-7 | | MF: | C39H67N5O7 | | MW: | 717.98 | | EINECS: | | | Mol File: | 474645-27-7.mol |  |
Use
Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.[Cayman Chemical]
- MonoMethyl auristatin E
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- US $30.00 / kg
- 2023-09-07
- CAS:474645-27-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000t/year
- MonoMethyl auristatin E
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- US $0.00 / KG
- 2023-05-20
- CAS:474645-27-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- MMAE;[3H]-Vedotin
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- US $15.00-10.00 / KG
- 2021-07-13
- CAS:474645-27-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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474645-27-7
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