| | 134036-52-5 Basic information More.. |
| Product Name: | AG 490 | | Synonyms: | AG 490, Tryphostin B42;2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide;N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide;TYRPHOSTIN AG 490;TYROPHOSTIN AG490;TYRPHOSTIN B42;TYRPHOSTIN AG 490, 99+%;N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide | | CAS: | 134036-52-5 | | MF: | C17H14N2O3 | | MW: | 294.3 | | EINECS: | 604-604-1 | | Mol File: | 134036-52-5.mol |  |
Use
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
|
|
134036-52-5
Recommend Suppliers |
|