| | 438-41-5 Basic information More.. |
| Product Name: | CHLORDIAZEPOXIDE HYDROCHLORIDE | | Synonyms: | CHLORDIAZEPOXIDE HYDROCHLORIDE--DEA SCHE DULE IV IT;CHLORDIAZEPOXIDE HYDROCHLORIDE;RO 5-0690;TRANUILIZER;7-CHLORO-2-[METHYLAMINO]-5-PHENYL-3H-1,4-BENZODIAZEPINE 4-OXIDE HYDROCHLORIDE;3h-1,4-benzodiazepin-2-amine,7-chloro-n-methyl-5-phenyl-,4-oxide,monohydro;3h-1,4-benzodiazepine,7-chloro-2-methylamino-5-phenyl-,4-oxide,monohydrochlo;ansiacal | | CAS: | 438-41-5 | | MF: | C16H15Cl2N3O | | MW: | 336.22 | | EINECS: | 207-117-8 | | Mol File: | 438-41-5.mol |  |
Use
Chlordiazepoxide hydrochloride, 7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine4-oxide monohydrochloride (Librium), is well absorbedafter oral administration. Peak plasma levels are reachedin 2 to 4 hours. The half-life of chlordiazepoxide is 6 to30 hours. N-demethylation and hydrolysis of the condensedamidino group are rapid and extensive, producing demoxepamas a major metabolite. Demoxepam can undergo fourdifferent metabolic fates. It is converted principally to itsactive metabolite nordazepam, which is also a major activemetabolite of diazepam, clorazepate, and prazepam.Nordazepam, in turn, is converted principally to active oxazepam(marketed separately), which conjugated to the excretedglucuronide. Because of the long half-life of parentdrug and its active metabolites, this drug is long acting andself-tapering. As with diazepam (vide infra), repeated administrationof chlordiazepoxide can result in accumulationof parent drug and its active metabolites, and thus cause excessivesedation.
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438-41-5
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