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4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole

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4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:308357-81-5
Package:500Mg,5g
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-BIS-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-2,6,10-TRIMETHYL-8-(PHENYLSULFONYL)UNDECA-1,5-DIENYL]-2-METHYL-1,3-THIAZOLE
CAS:308357-81-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:308357-81-5
Purity:98%
Company Name: S.Z. PhyStandard Bio-Tech. Co., Ltd.  
Tel: 0755-83725681-603
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Products Intro: Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:308357-81-5
Package:Mg Remarks:TRC
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Products Intro: Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:308357-81-5
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Basic information
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Synonyms:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole;4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-8-(phenylsulfonyl)-1,5-undecadi;Thiazole, 4-[(1E,3S,5Z,10S)-3,11-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-8-(phenylsulfonyl)-1,5-undecadien-1-yl]-2-methyl-;Paclitaxel Impurity 74
CAS:308357-81-5
MF:C36H61NO4S2Si2
MW:692.17
EINECS:
Product Categories:Chiral Reagents
Mol File:308357-81-5.mol
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Structure
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Chemical Properties
Boiling point 691.6±55.0 °C(Predicted)
density 1.027±0.06 g/cm3(Predicted)
solubility Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
pka2.72±0.10(Predicted)
form Oil
color Colourless
CAS DataBase Reference308357-81-5
Safety Information
MSDS Information
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Usage And Synthesis
Chemical PropertiesColourless Oil
UsesAn intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Preparation Products And Raw materials
Raw materialsThiazole, 4-[(1E,3S,5Z)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-iodo-2,6-dimethyl-1,5-heptadien-1-yl]-2-methyl--->(3S)-4-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-3-METHYLBUTYL PHENYL SULFONE-->(-)-(3S)-3-([TERT-BUTYL(DIMETHYL)SILYL]OXY)DIHYDROFURAN-2(3H)-ONE
Tag:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole(308357-81-5) Related Product Information
(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 7-Xylosyl-10-deacetyltaxol Paclitaxel Impurity 9 N-Desbenzoyl-N-tert-butoxycarbonyl-N,O-isopropylidene-3a€-p-O-benzyl-6,7-dehydro Paclitaxel 2'-O-(Benzyloxycarbonyl) Taxol (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE Epothilone B 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Docetaxel-D9 Paclitaxel EP Impurity I (4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester 13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(triethylsilyl) Baccatin III DHA-paclitaxel 2',7-Bis-O-(Triethylsilyl) 10-Desacetyl Paclitaxel