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| Products Intro: |
Product Name:d4TMP
CAS:3715-64-8
Purity:95% by HPLC
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| | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Basic information |
| Product Name: | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | | Synonyms: | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;2',3'-Didehydro-3'-deoxythymidine 5'-phosphoric acid;3'-Deoxy-2',3'-didehydro-5'-thymidylic acid;3'-Deoxy-2',3'-didehydrothymidine 5'-phosphoric acid;D4-TMP;D4T-MP;(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate;5'-Thymidylic acid, 3'-deoxy- | | CAS: | 3715-64-8 | | MF: | C10H15N2O7P | | MW: | 306.21 | | EINECS: | | | Product Categories: | | | Mol File: | 3715-64-8.mol |  |
| | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical Properties |
| density | 1.547±0.06 g/cm3(Predicted) | | pka | 1.86±0.10(Predicted) |
| | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Usage And Synthesis |
| Uses | 3`-Deoxy-5`-thymidylic Acid has been shown to complex with human thymidylate kinase via hydrogen bonding between Arg97 residues and phosphate groups. This interaction leads to the closed P-loop conformation in human thymidylate kinase, which promotes phosphorylation of nucleotides and has the potential as a model for novel compounds as a result of structure-based design studies. |
| | 1-(5-O-Phosphono-2,3-dideoxy-β-D-glycero-penta-2-enofuranosyl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione Preparation Products And Raw materials |
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