| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:TaMoxifen-13C6;(Z)-2-[4-[1-(phenyl-13C6)-2-phenyl-1-butenyl]phenoxy]-N,N-diMethylethanaMine; ICI 47699-13C6; MaMMaton-13C6; Novaldex-13C6; TaMoxifen-13C6; Z-TaMoxifen-13C6;
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
|
| | TaMoxifen-13C6 Basic information |
| | TaMoxifen-13C6 Chemical Properties |
| Melting point | 94 - 99°C | | storage temp. | Amber Vial, -20°C Freezer | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White |
| | TaMoxifen-13C6 Usage And Synthesis |
| Uses | A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxy
tamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimula
ted VEGF production in breast tumor cells.
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective e
strogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. |
| | TaMoxifen-13C6 Preparation Products And Raw materials |
|