| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:MLS-573151
CAS:10179-57-4
Purity:>98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:2g
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:MLS-573151
CAS:10179-57-4
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | MLS-573151 Basic information |
| Product Name: | MLS-573151 | | Synonyms: | MLS-573151;Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-;4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;MLS-573151,granulocytes,Inhibitor,Ras,inhibit,MLS-000573151,MLS 000573151,GTPase,MLS 573151,Cdc42,MLS573151,MLS000573151 | | CAS: | 10179-57-4 | | MF: | C21H19N3O2S | | MW: | 377.46 | | EINECS: | | | Product Categories: | | | Mol File: | 10179-57-4.mol |  |
| | MLS-573151 Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 20 mg/ml). | | form | solid | | color | Yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| | MLS-573151 Usage And Synthesis |
| Description | The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42. | | Uses | The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.[Cayman Chemical] | | in vitro | mls-573151 was a specific, cell permeable inhibitor of cdc42 with an ic50 of 2 μm [1]. mls-573151 showed no effect on other gtpases, including the related rho family members rhoa, rac1, and rac2. mls-573151 functioned by blocking the binding of gtp to cdc42 [1]. in marrow-derived mesenchymal stem cells, mls-573151 showed no effect on cell migration [3]. | | References | 1) Surviladze et al. (2010), Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay; J. Biomol. Screening, 15 10
2) Wang et al. (2017), Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury; J. Cell Physiol., 232 110 |
| | MLS-573151 Preparation Products And Raw materials |
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