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| Product Name: | TMS | | Synonyms: | (E)-2,3',4,5'-TETRAMETHOXYSTILBENE;2,3',4,5'-TETRAMETHOXYSTILBENE;1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE;3,5,2’,4’-Tetramethoxystilbene;Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene;TMS, >=98% | | CAS: | 24144-92-1 | | MF: | C18H20O4 | | MW: | 300.35 | | EINECS: | | | Product Categories: | Antitumour | | Mol File: | 24144-92-1.mol |  |
| Melting point | 78-79 °C | | Boiling point | 459.9±40.0 °C(Predicted) | | density | 1.117±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml | | form | Powder |
| Uses | 2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells. | | Uses | CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml. | | Uses | 2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells. | | Definition | ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid. | | Biological Activity | Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro . |
| | TMS Preparation Products And Raw materials |
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