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Product Name: | IWP-O1 | Synonyms: | IWP-O1;IWO-O1;IWP-O1(17);1H-1,2,3-Triazole-1-acetamide, 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-;IWP-O1 >=98% (HPLC);2-(5-Phenyl-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)-N-(5-phenylpyridin-2-yl)acetamide;Wnt,IWP-O-1,Porcupine,IWPO1,inhibit,Inhibitor,IWP-O1,IWP O1 | CAS: | 2074607-48-8 | MF: | C26H20N6O | MW: | 432.48 | EINECS: | | Product Categories: | | Mol File: | 2074607-48-8.mol | |
| IWP-O1 Chemical Properties |
storage temp. | 2-8°C(protect from light) | solubility | DMSO : 125 mg/mL (289.03 mM);Water : < 0.1 mg/mL (insoluble) |
| IWP-O1 Usage And Synthesis |
Biological Activity | IWP-O1 is a porcn inhibitor with an EC50 of 80 pM in a Wnt signaling reporter assay in cultured cells. It can effectively inhibit the phosphorylation of Dvl2/3 in Hela cells. | in vitro | IWP-O1 has good metabolic stability. | target | Target | Value | porcn (Cell-based assay) | 80 pM(EC50) |
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| IWP-O1 Preparation Products And Raw materials |
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