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| | NSC632839hydrochloride Basic information |
| Product Name: | NSC632839hydrochloride | | Synonyms: | Ubiquitin Isopeptidase Inhibitor II, F6;NSC 632839;4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride;NSC632839hydrochloride;3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride;NSC 632839;NSC-632839;Ubiquitin Isopeptidase Inhibitor II;NSC632839 HCl | | CAS: | 157654-67-6 | | MF: | C21H21NO.ClH | | MW: | 339.864 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 157654-67-6.mol |  |
| | NSC632839hydrochloride Chemical Properties |
| storage temp. | Store at +4°C | | solubility | DMSO: ≥2mg/mL (warmed) | | form | powder | | color | faint yellow to dark yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Codes | Xi,N | | Risk Statements | 36-51/53 | | Safety Statements | 26-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| | NSC632839hydrochloride Usage And Synthesis |
| Description | NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable. | | Uses | Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene). | | Biological Activity | Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively). | | References | 1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235
2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035 |
| | NSC632839hydrochloride Preparation Products And Raw materials |
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