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| | N-Methylconanin-5-en-3β-amine Basic information |
| | N-Methylconanin-5-en-3β-amine Chemical Properties |
| Melting point | 92°C | | Boiling point | 238-240 °C | | density | 1.05±0.1 g/cm3(Predicted) | | pka | 10.52±0.60(Predicted) |
| | N-Methylconanin-5-en-3β-amine Usage And Synthesis |
| Description | A pregnene type alkaloid found in the bark and seeds of Holarrhena antidysenterica Wall., the base yields a hydrate, m.p. 88-92°C and has [α]25D + 30.0°
(aqueous EtOH). It is freely soluble in most organic solvents. It yields a series of
crystalline salts and derivatives, e.g. the hydrochloride, m.p. 334-335°C (dec.);
hydrobromide, m.p. 344°C; hydriodide, m.p. 316°C; platinichloride, m.p. 285°C (dec.); methiodide, m.p. 290°C (dec.) and the picrate, m.p. 198-200°C. The
N-acetyl derivative has also been prepared, m.p. 161°C yielding a hydrochloride,
m.p. 325-6°C, as has the benzoyl compound, m.p. l59-l60°C, also forming a
hydrochloride, m.p. 325-6°C (dec.).
On methylation, the alkaloid yields conessine and heating with dilute H2S04
isomerizes the base to isonorisoconessine, [0:]5S + 101 ° (EtOH), furnishing a
hydriodide, m.p. 289°C (dec.) and a picrate, m.p. 166°C. | | References | Siddiqui.,J. Ind. Chern. Soc., 11,283 (1934)
Siddiqui, Siddiqui., ibid, 11,787 (1934)
Haworth, McKenna, Whitfield.,J. Chern. Soc., 1102 (1953) |
| | N-Methylconanin-5-en-3β-amine Preparation Products And Raw materials |
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