| Company Name: |
Chemicea Pharmaceuticals Pvt Ltd
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| Tel: |
+91-918482849343 +91-8482849343 |
| Email: |
exports@chemicea.com |
| Products Intro: |
Product Name:DIAZEPAM - IN HOUSE IMPURITY
CAS:784-41-8
Purity:99% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:2-AMino-5-chloro-4'-hydroxybenzophenone
CAS:784-41-8
Package:100Mg,250Mg,25Mg
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| | 2-AMino-5-chloro-4'-hydroxybenzophenone Basic information |
| Product Name: | 2-AMino-5-chloro-4'-hydroxybenzophenone | | Synonyms: | 2-AMino-5-chloro-4'-hydroxybenzophenone;Methanone, (2-amino-5-chlorophenyl)(4-hydroxyphenyl)-;DIAZEPAM - IN HOUSE IMPURITY;(2-Amino-5-chloro-phenyl)-(4-hydroxy-phenyl)-methanone | | CAS: | 784-41-8 | | MF: | C13H10ClNO2 | | MW: | 247.68 | | EINECS: | | | Product Categories: | | | Mol File: | 784-41-8.mol |  |
| | 2-AMino-5-chloro-4'-hydroxybenzophenone Chemical Properties |
| Melting point | 174°C | | solubility | soluble in DCM, Ethyl Acetate | | form | Solid | | color | Yellow |
| | 2-AMino-5-chloro-4'-hydroxybenzophenone Usage And Synthesis |
| Uses | 2-Amino-5-chloro-4'-hydroxybenzophenone is an intermediate in the preparation of Diazepam (D416855), an anxiolytic agent, muscle relaxant and anticonvulsant agent. | | Preparation | Preparation by cleavage of 5-chloro-3-(phydroxyphenyl)- 2,1-benzisoxazole (other name: 5-chloro-3-(p-hydroxy-phenyl)anthranil) (SM),
? by heating at reflux with aluminium iodide for 50 min (87%);
? by reaction with concentrated hydrochloric acid and an excess of tin in boiling ethanol or acetic acid. SM (m.p. 241°) was prepared by condensation of o-nitrobenzaldehyde with phenol in the presence of hydrogen chloride or phosphorous oxychloride in cold acetic acid;
? by hydrogenation in the presence of 10% Pd/C in ethyl acetate between 40° and 60° at a pressure of 3 atmospheres (quantitative yield). |
| | 2-AMino-5-chloro-4'-hydroxybenzophenone Preparation Products And Raw materials |
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