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| | 3D-(6-ACYL) PHAD Basic information |
| Product Name: | 3D-(6-ACYL) PHAD | | Synonyms: | 3D-(6-ACYL) PHAD;3D-PHAD,3D-MPL;D-Glucose, 2-deoxy-6-O-[2-deoxy-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-;(2R,3S,4R,5R,6R)-2-(hydroxymethyl)-3-phosphonooxy-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]-6-[(2R,3S,4R,5R)-2,3,4-trihydroxy-6-oxo-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]hexoxy]oxan-4-yl] (3R)-3-tetradecanoyloxytetra decanoate | | CAS: | 252042-59-4 | | MF: | C96H181N2O21P | | MW: | 1730.47 | | EINECS: | | | Product Categories: | | | Mol File: | 252042-59-4.mol |  |
| | 3D-(6-ACYL) PHAD Chemical Properties |
| density | 1.08±0.1 g/cm3(Predicted) | | pka | 1.83±0.10(Predicted) |
| | 3D-(6-ACYL) PHAD Usage And Synthesis |
| Uses | 3D-(6-acyl) PHAD? has been used:
- as a synthetic adjuvant in human papillomavirus (HPV) and virus-like particles (VLPs)-based HPV vaccine preparations
- as a component of liposomes for immunizing mice with P. falciparum (Pfs25) malaria transmission-blocking vaccine antigen candidate
- in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice
| | General Description | Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD?), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines. |
| | 3D-(6-ACYL) PHAD Preparation Products And Raw materials |
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