4,6-二氨基-5-甲酰胺基嘧啶
| 中文名称 | 4,6-二氨基-5-甲酰胺基嘧啶 |
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| 中文同义词 | 4,6-二氨基-5-甲酰基氨基嘧啶盐酸盐;4,6-二氨基-5-甲酰胺基嘧啶;4,6-二氨基-5-甲酰胺基嘧啶盐酸盐;4,6-二氨基-5-甲酰基氨基嘧啶;二氨基-15N2,98%);法比腺嘌呤(甲酰-13C,98%;腺苷杂质33;N-(4,6-DIAMINOPYRIMIDIN-5-YL)甲酰胺 |
| 英文名称 | 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE |
| 英文同义词 | 4,6-diamino-5-n-formamidopyrimidine;4,6-Diaminobenzene-5-formamidopyrimide-formyl-13C, diamino-15N2;4,6-DIAMONO-5-(FORMYLAMINO)PYRIMIDNE;FAPy-adenine;DIAMINO-15N2);FAPYADENINE(FORMYL-13C;DIAMINO-15N2, 98%);4,6-Diamino-5-(Formylamino)-Pyrimidine HCl |
| CAS号 | 5122-36-1 |
| 分子式 | C5H7N5O |
| 分子量 | 153.14 |
| EINECS号 | 200-258-5 |
| 相关类别 | 同位素标记物;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol文件 | 5122-36-1.mol |
| 结构式 |  |
4,6-二氨基-5-甲酰胺基嘧啶 性质
| 熔点 | 224-226 °C |
|---|---|
| 沸点 | 536.1±50.0 °C(Predicted) |
| 密度 | 1.575±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 12.35±0.70(Predicted) |
FAPy-adenine 是一种氧化的 DNA 碱基。FAPy-adenine 在阿尔茨海默病脑中呈上升趋势。氧化核苷是肿瘤、衰老和神经退行性疾病的生化标志物。
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Human Endogenous Metabolite
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In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-113303 | FAPy-adenine | 5 mg | 625元 | |
| 2024/04/30 | HY-113303 | 4,6-二氨基-5-甲酰胺基嘧啶 FAPy-adenine | 5122-36-1 | 10mM * 1mLin DMSO | 1100元 |