SAREDUTANT
| 中文名称 | SAREDUTANT |
|---|---|
| 中文同义词 | 化合物 T16842 |
| 英文名称 | Saredutant |
| 英文同义词 | SR 48968;(S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide;Benzamide, N-((2S)-4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-;Benzamide, N-(4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-, (S)-;Sr 48968c |
| CAS号 | 142001-63-6 |
| 分子式 | C31H35Cl2N3O2 |
| 分子量 | 552.53 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 142001-63-6.mol |
| 结构式 |  |
SAREDUTANT 性质
| 沸点 | 734.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/ml（452.46 mM） |
| 酸度系数(pKa) | 15.88±0.20(Predicted) |
Saredutant 是一种选择性 NK2 受体拮抗剂。
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NK2
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Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility.