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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
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Product Name:N-(2-Phenylethyl)indoMethacin AMide
CAS:261766-32-9
Package:500Mg,50Mg
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
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Product Name:N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
CAS:261766-32-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Chemsky (shanghai) International Co.,Ltd
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021-50135380 |
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shchemsky@sina.com |
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Product Name:N-(2-Phenylethyl)indoMethacin AMide;N-(2-Phenylethyl)-1-p-chlorobenzoyl-5-Methoxy-2-Methylindole-3-acetaMide; 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide
CAS:261766-32-9
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627 |
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info@efebio.com |
| Products Intro: |
Product Name:N-(2-Phenylethyl)indomethacin Amide
CAS:261766-32-9
Purity:98% Package:1mg;5mg;10mg
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| | N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Basic information |
| | N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Chemical Properties |
| Boiling point | 640.5±55.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | ≤80mg/ml in ethanol;10mg/ml in DMSO;14mg/ml in dimethyl formamide | | pka | 15.12±0.46(Predicted) | | form | Pale yellow solid. |
| | N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Usage And Synthesis |
| Uses | N-(2-Phenylethyl)indomethacin Amide is an aromatic amide of indomethacin reported to be a potent and selective reversible inhibitor of COX-2. N-(2-Phenylethyl)indomethacin Amide inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively. | | Uses | An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively | | Definition | ChEBI: N-(2-phenylethyl)-Indomethacin amide is a N-acylindole. | | Biological Activity | n-(2-phenylethyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(2-phenylethyl)-indomethacin amide (n-2pia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.06 and >66 μm, respectively. it is over 1000 times less potent as an inhibitor of ovine cox-1. n-(2-phenylethyl)-indomethacin amide is an analogous derivative of indomethacin that shows selective against cox-2 [1].in the carageenan-induced foot pad edema assay, orally administration of n-2pia showed anti-inflammatory activity [1]. | | references | [1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70. |
| | N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials |
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