110816-78-9
| 中文名称 | 110816-78-9 |
|---|---|
| 中文同义词 | 化合物 T15676 |
| 英文名称 | N 556 |
| 英文同义词 | N 556;5,5'-[[2-(Lysyloxy)propane-1,3-diyl]bisoxy]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl]·2hydrochloride;KY-556;KY556,KY 556 |
| CAS号 | 110816-78-9 |
| 分子式 | C33H36N2O12.2ClH |
| 分子量 | 725.571 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 110816-78-9.mol |
| 结构式 |  |
110816-78-9 性质
| 熔点 | 225-228 °C |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
KY-556 是一种针对过敏性疾病的具有口服活性的色甘酸二钠 (DSCG) 的前药。
The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats.