| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:β-Gal-NONOate
CAS:357192-77-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:β-Gal-NONOate
CAS:357192-77-9
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:β-Gal-NONOate
CAS:357192-77-9
Package:>=98% Remarks:10009137
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| | β-Gal-NONOate Basic information |
| Product Name: | β-Gal-NONOate | | Synonyms: | β-Gal-NONOate;(E)-oxido-pyrrolidin-1-yl-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyiminoazanium;β-D-Galactopyranose, 1-O-[2-oxido-2-(1-pyrrolidinyl)diazenyl]-;β-Gal-NONOate | | CAS: | 357192-77-9 | | MF: | C10H19N3O7 | | MW: | 293.27 | | EINECS: | | | Product Categories: | | | Mol File: | 357192-77-9.mol |  |
| | β-Gal-NONOate Chemical Properties |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 2 mg/ml | | form | A crystalline solid |
| | β-Gal-NONOate Usage And Synthesis |
| Description | β-Gal-NONOate is a nitric oxide (NO) donor which releases NO following activation by β-galactosidase.1 β-Gal-NONOate is stable in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic hydrolysis, β-Gal-NONOate decomposes with a half-life of six minutes at pH 5.6.1 β-Gal-NONOate is cytotoxic to a number of cancer cell-lines and exhibits high bactericidal activity against E. coli transformed with the β-galactosidase gene.1,2 | | References | 1. Wu, X., Tang, X., Xian, M., et al. Glycosylated diazeniumdiolates: A novel class of enzyme-activated nitric oxide donors Tetrahedron Lett. 42(23),3779-3782(2001).
2. Chen, C., Shi, Y.Q., Song, J., et al. Delivery of nitric oxide released from β-Gal-NONOate activation by β-galactosidase and its activity against Escherichia coli Biol. Pharm. Bull. 29(6),1239-1241(2006). |
| | β-Gal-NONOate Preparation Products And Raw materials |
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